Huang Chiang-Chi, Liu Hui-Ying, Hsu Tsuen-Wei, Lee Wen-Chin
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Biomedicines. 2022 Oct 1;10(10):2453. doi: 10.3390/biomedicines10102453.
Mitochondria are important organelles responsible for energy production, redox homeostasis, oncogenic signaling, cell death, and apoptosis. Deregulated mitochondrial metabolism and biogenesis are often observed during cancer development and progression. Reports have described the crucial roles of mitochondria in urothelial carcinoma (UC), which is a major global health challenge. This review focuses on research advances in the role of mitochondria in UC. Here, we discuss the pathogenic roles of mitochondria in UC and update the mitochondria-targeted therapies. We aim to offer a better understanding of the mitochondria-modulated pathogenesis of UC and hope that this review will allow the development of novel mitochondria-targeted therapies.
线粒体是负责能量产生、氧化还原稳态、致癌信号传导、细胞死亡和凋亡的重要细胞器。在癌症发生和发展过程中，经常观察到线粒体代谢和生物合成失调。有报道描述了线粒体在尿路上皮癌（UC）中的关键作用，尿路上皮癌是一项重大的全球健康挑战。本综述重点关注线粒体在尿路上皮癌中作用的研究进展。在此，我们讨论线粒体在尿路上皮癌中的致病作用，并更新针对线粒体的治疗方法。我们旨在更好地理解线粒体调节的尿路上皮癌发病机制，并希望本综述能推动新型线粒体靶向治疗方法的开发。
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