Koga Takuma, Okamoto Masaki, Satoh Minoru, Fujimoto Kiminori, Zaizen Yoshiaki, Chikasue Tomonori, Sumi Akiko, Kaieda Shinjiro, Matsuo Norikazu, Matama Goushi, Nouno Takashi, Tominaga Masaki, Yatera Kazuhiro, Ida Hiroaki, Hoshino Tomoaki
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
Department of Respirology and Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-0065, Japan.
Biomedicines. 2022 Oct 2;10(10):2469. doi: 10.3390/biomedicines10102469.
Various autoantibodies are associated with clinical outcomes in patients with idiopathic interstitial pneumonias (IIPs). We retrospectively analyzed the association between autoantibodies and malignancies in IIP patients. Comprehensive analyses of autoantibodies were performed using immunoprecipitation and enzyme-linked immunosorbent assays in 193 consecutive IIP patients. Cancer-related factors were analyzed using logistic regression analysis. In total, 22 of 193 patients (11.4%) with IIP had malignant disease. In univariate analysis, positivity for any autoantibody (odds ratio (OR), 3.1; 95% confidence interval (CI), 1.2-7.7; = 0.017) and antinuclear antibody titer ≥1:320 (OR, 3.4; CI, 1.2-9.8; = 0.024) were significantly associated with malignancies. Positive anti-aminoacyl tRNA synthetase (ARS) (OR, 3.7; CI, 0.88-15.5; = 0.074) and anti-Ro52 antibody (OR, 3.2; CI, 0.93-11.2; = 0.065) tended to be associated with malignancies. In multivariate analysis, independent risk factors were male sex (OR, 3.7; CI, 1.0-13.5; = 0.029) and positivity for any autoantibody (OR, 3.9; CI, 1.5-10.1; = 0.004) in model 1, and male sex (OR, 3.9; CI, 1.0-15.3; = 0.049), antinuclear antibody titer ≥1:320 (OR, 4.2; CI, 1.4-13.3; = 0.013), and positivity for anti-ARS antibody (OR, 6.5; CI, 1.2-34.1; = 0.026) in model 2. Positivity for any autoantibody, antinuclear and anti-ARS antibodies, and male sex were independent risk factors for malignancies in IIP patients. Testing autoantibodies in IIP patients might help the early diagnosis of malignancies.
多种自身抗体与特发性间质性肺炎（IIP）患者的临床结局相关。我们回顾性分析了IIP患者自身抗体与恶性肿瘤之间的关联。对193例连续的IIP患者采用免疫沉淀和酶联免疫吸附试验对自身抗体进行了综合分析。使用逻辑回归分析对癌症相关因素进行了分析。193例IIP患者中共有22例（11.4%）患有恶性疾病。在单因素分析中，任何自身抗体阳性（比值比（OR），3.1；95%置信区间（CI），1.2 - 7.7；P = 0.017）和抗核抗体滴度≥1:320（OR，3.4；CI，1.2 - 9.8；P = 0.024）与恶性肿瘤显著相关。抗氨酰tRNA合成酶（ARS）抗体阳性（OR，3.7；CI，0.88 - 15.5；P = 0.074）和抗Ro52抗体阳性（OR，3.2；CI，0.93 - 11.2；P = 0.065）倾向于与恶性肿瘤相关。在多因素分析中，模型1中的独立危险因素为男性（OR，3.7；CI，1.0 - 13.5；P = 0.029）和任何自身抗体阳性（OR，3.9；CI，1.5 - 10.1；P = 0.004），模型2中的独立危险因素为男性（OR，3.9；CI，1.0 - 15.3；P = 0.049）、抗核抗体滴度≥1:320（OR，4.2；CI，1.4 - 13.3；P = 0.013）和抗ARS抗体阳性（OR，6.5；CI，1.2 - 34.1；P = 0.026）。任何自身抗体、抗核抗体和抗ARS抗体阳性以及男性是IIP患者发生恶性肿瘤的独立危险因素。检测IIP患者的自身抗体可能有助于恶性肿瘤的早期诊断。
