Almutairi Farooq M, Ullah Aman, Althobaiti Yusuf S, Irfan Hafiz Muhammad, Shareef Usman, Usman Halima, Ahmed Sagheer
Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, University of Hafr Al-Batin, Hafr Al-Batin 39524, Saudi Arabia.
Saba Medical Center, Abu Dhabi P.O. Box 20316, United Arab Emirates.
Biomedicines. 2022 Oct 13;10(10):2566. doi: 10.3390/biomedicines10102566.
Stroke is a serious condition that results from an occlusion of blood vessels that leads to brain damage. Globally, it is the second highest cause of death, and deaths from strokes are higher in older people than in the young. There is a higher rate of cases in urban areas compared to rural due to lifestyle, food, and pollution. There is no effective single medicine for the treatment of stroke due to the multiple causes of strokes. Thrombolytic agents, such as alteplase, are the main treatment for thrombolysis, while multiple types of surgeries, such ascraniotomy, thrombectomy, carotid endarterectomy, and hydrocephalus, can be performed for various forms of stroke. In this review, we discuss some promising phytocompounds, such as flavone C-glycoside (apigenin-8-C-β-D-glucopyranoside), eriodictyol, rosamirinic acid, 6″--succinylapigenin, and allicin, that show effectiveness against stroke. Future study paths are given, as well as suggestions for expanding the use of medicinal plants and their formulations for stroke prevention.
中风是一种严重的疾病，由血管阻塞导致脑损伤引起。在全球范围内，它是第二大死因，老年人中风死亡人数高于年轻人。由于生活方式、饮食和污染，城市地区的发病率高于农村地区。由于中风的病因多种多样，目前尚无有效的单一药物治疗中风。溶栓药物，如阿替普酶，是溶栓的主要治疗方法，而多种类型的手术，如开颅手术、血栓切除术、颈动脉内膜切除术和脑积水手术，可用于治疗各种形式的中风。在这篇综述中，我们讨论了一些有前景的植物化合物，如黄酮C-糖苷（芹菜素-8-C-β-D-吡喃葡萄糖苷）、圣草酚、迷迭香酸、6″-琥珀酰芹菜素和大蒜素，它们对中风显示出有效性。同时给出了未来的研究方向，以及扩大药用植物及其制剂用于中风预防的使用建议。
