Delcorte Ophélie, Degosserie Jonathan, Pierreux Christophe E
CELL Unit, de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.
Department of Laboratory Medicine, Molecular Diagnostic Center, CHU UCL Namur, 5530 Yvoir, Belgium.
Biomedicines. 2022 Oct 15;10(10):2585. doi: 10.3390/biomedicines10102585.
Extracellular vesicles are spherical subcellular structures delimited by a lipid bilayer and released by most cells in the human body. They are loaded with a myriad of molecules (i.e., nucleic acids and proteins) depending on their cell of origin and provide the ability to transmit a message to surrounding or distant target cells. In several organs, including the thyroid, abundant recent literature reports that extracellular vesicles are responsible for intercellular communication in physiological and pathological processes, and that their utilization as a potential biomarker of pathological states (i.e., cancer, autoimmune diseases) or as therapeutic delivery vehicles promise clinical options. In this review, we present the current knowledge and understanding regarding the role of extracellular vesicles in developing thyroid diseases and diagnosis.
细胞外囊泡是由脂质双层界定的球形亚细胞结构，由人体中的大多数细胞释放。它们根据其来源细胞装载了无数分子（即核酸和蛋白质），并具有向周围或远处靶细胞传递信息的能力。在包括甲状腺在内的多个器官中，最近有大量文献报道，细胞外囊泡在生理和病理过程中负责细胞间通讯，并且将其用作病理状态（即癌症、自身免疫性疾病）的潜在生物标志物或治疗递送载体有望带来临床选择。在本综述中，我们介绍了关于细胞外囊泡在甲状腺疾病发展和诊断中的作用的当前知识和理解。
