家族性高胆固醇血症作为动脉粥样硬化的一个易感因素。

Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis.

作者信息

Poznyak Anastasia V, Litvinova Larisa, Poggio Paolo, Orekhov Alexander N, Melnichenko Alexandra A

机构信息

Institute for Atherosclerosis Research, Osennyaya 4-1-207, Moscow 121609, Russia.

Center for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 6 Gaidara Street, Kaliningrad 236001, Russia.

出版信息

Biomedicines. 2022 Oct 20;10(10):2639. doi: 10.3390/biomedicines10102639.

DOI:10.3390/biomedicines10102639

PMID:36289901

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9599590/

Abstract

Lipid metabolism alterations are an important component of the pathogenesis of atherosclerosis. However, it is now clear that the atherogenesis process involves more than one mechanism, and more than one condition can predispose this condition. Multiple risk factors contribute to the atherosclerosis initiation and define its course. Familial hypercholesterolaemia is a disorder of lipid metabolism that often leads to atherosclerosis development. As is clear from the disease name, the hallmark is the increased levels of low-density lipoprotein cholesterol (LDL-C) in blood. This creates favourable conditions for atherogenesis. In this review, we briefly described the familial hypercholesterolaemia and summarized data on the relationship between familial hypercholesterolaemia and atherosclerosis.

摘要

脂质代谢改变是动脉粥样硬化发病机制的重要组成部分。然而，现在很清楚，动脉粥样硬化的发生过程涉及多种机制，多种情况都可能引发这种疾病。多种危险因素促成动脉粥样硬化的发生并决定其发展进程。家族性高胆固醇血症是一种脂质代谢紊乱疾病，常导致动脉粥样硬化的发展。从疾病名称可以看出，其特征是血液中低密度脂蛋白胆固醇（LDL-C）水平升高。这为动脉粥样硬化的发生创造了有利条件。在本综述中，我们简要描述了家族性高胆固醇血症，并总结了家族性高胆固醇血症与动脉粥样硬化之间关系的数据。