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皮肤、肝脏和肾脏的相互作用导致衰老的KK-Ay/Tajcl小鼠皮肤干燥。

Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice.

作者信息

Hiramoto Keiichi, Goto Kenji, Tanaka Shota, Horikawa Tsuneki, Ooi Kazuya

机构信息

Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan.

Research Laboratories, Nichinichi Pharmaceutical Co., Ltd., Iga 518-1417, Japan.

出版信息

Biomedicines. 2022 Oct 20;10(10):2648. doi: 10.3390/biomedicines10102648.

DOI:10.3390/biomedicines10102648
PMID:36289909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9599438/
Abstract

Type 2 diabetes is a lifestyle-related disease that affects people worldwide and is especially prevalent in the elderly. Many elderly people with diabetes also complain of dry skin; however, the relationship between aging and dry skin in type 2 diabetes is unknown. The purpose of this study was to examine the interaction between aging and dry skin using the specific pathogen-free KK-Ay/TaJcl type 2 diabetes mouse model. Skin dryness in this model increases with age and was evaluated at 10, 27, 40, and 50 weeks. We observed increased mast cell expression, increased histamine and matrix metalloproteinase-1 levels, and decreased collagen expression in the skin of aging KK-Ay/TaJcl mice. In addition, the increased expression of angiopoietin 2, interleukin-6, tumor necrosis factor-α, and endostatin in the blood indicated kidney damage in this model. Aging KK-Ay/TaJcl mice also showed fatty liver pathology, which led to increased reactive oxygen species in the blood and liver, as well as the increased expression of M1 macrophages in the liver. These results showed that dry skin is associated with skin, kidney, and liver interactions in an aging type 2 diabetes mouse model.

摘要

2型糖尿病是一种与生活方式相关的疾病，影响着全世界的人们，在老年人中尤为普遍。许多老年糖尿病患者也抱怨皮肤干燥；然而，2型糖尿病中衰老与皮肤干燥之间的关系尚不清楚。本研究的目的是使用无特定病原体的KK-Ay/TaJcl 2型糖尿病小鼠模型来研究衰老与皮肤干燥之间的相互作用。该模型中的皮肤干燥程度随年龄增长而增加，并在10、27、40和50周时进行评估。我们观察到衰老的KK-Ay/TaJcl小鼠皮肤中肥大细胞表达增加、组胺和基质金属蛋白酶-1水平升高以及胶原蛋白表达降低。此外，血液中血管生成素2、白细胞介素-6、肿瘤坏死因子-α和内皮抑素表达的增加表明该模型存在肾脏损伤。衰老的KK-Ay/TaJcl小鼠还表现出脂肪肝病理，这导致血液和肝脏中的活性氧增加，以及肝脏中M1巨噬细胞的表达增加。这些结果表明，在衰老的2型糖尿病小鼠模型中，皮肤干燥与皮肤、肾脏和肝脏的相互作用有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/888bceffeba3/biomedicines-10-02648-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/d3e66e5db539/biomedicines-10-02648-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/d984a09d04ca/biomedicines-10-02648-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/63aac71f266c/biomedicines-10-02648-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/6d477a9ee97b/biomedicines-10-02648-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/ba962a0169e1/biomedicines-10-02648-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/48818b64907a/biomedicines-10-02648-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/bfe8e1bf3dfe/biomedicines-10-02648-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/888bceffeba3/biomedicines-10-02648-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/d3e66e5db539/biomedicines-10-02648-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/d984a09d04ca/biomedicines-10-02648-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/63aac71f266c/biomedicines-10-02648-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/6d477a9ee97b/biomedicines-10-02648-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/ba962a0169e1/biomedicines-10-02648-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/48818b64907a/biomedicines-10-02648-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/bfe8e1bf3dfe/biomedicines-10-02648-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/9599438/888bceffeba3/biomedicines-10-02648-g008.jpg

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