AGE/巨噬细胞/TNF-α通路的变化在KK-Ay/Tajcl小鼠衰老过程中影响皮肤干燥。

Changes in the AGE/Macrophage/TNF-α Pathway Affect Skin Dryness during KK-Ay/Tajcl Mice Aging.

作者信息

Hiramoto Keiichi, Imai Masashi, Tanaka Shota, Ooi Kazuya

机构信息

Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan.

出版信息

Life (Basel). 2023 Jun 7;13(6):1339. doi: 10.3390/life13061339.

DOI:10.3390/life13061339

PMID:37374121

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10304917/

Abstract

Skin dryness associated with type 2 diabetes worsens with age; however, the underlying mechanisms remain unclear. Herein, we investigated the effects of aging on skin dryness using a type 2 diabetes mice model. Specific pathogen-free KK-Ay/TaJcl mice of different ages (10, 27, 40, and 50 weeks) were used in this study. The results confirmed that skin dryness worsens with age. Furthermore, increased levels of advanced glycation end products (AGE), prostaglandin E2 (PGE2), and tumor necrosis factor (TNF)-α, along with an increased expression of the major AGE receptor (RAGE), an increased macrophage number, and decreased collagen expression were observed in the skin of aged KK-Ay/TaJcl mice. In conclusion, dry skin conditions worsen with age in diabetic mice, and the AGE/RAGE/PGE2 and TNF-α pathways play an important role in exacerbating skin dryness during aging in these mice.

摘要

2型糖尿病相关的皮肤干燥会随着年龄增长而加重；然而，其潜在机制仍不清楚。在此，我们使用2型糖尿病小鼠模型研究了衰老对皮肤干燥的影响。本研究使用了不同年龄（10、27、40和50周）的无特定病原体KK-Ay/TaJcl小鼠。结果证实皮肤干燥会随着年龄增长而加重。此外，在老年KK-Ay/TaJcl小鼠的皮肤中观察到晚期糖基化终产物（AGE）、前列腺素E2（PGE2）和肿瘤坏死因子（TNF）-α水平升高，同时主要AGE受体（RAGE）的表达增加、巨噬细胞数量增加以及胶原蛋白表达减少。总之，糖尿病小鼠的皮肤干燥状况会随着年龄增长而恶化，AGE/RAGE/PGE2和TNF-α途径在这些小鼠衰老过程中加剧皮肤干燥方面发挥着重要作用。