Tsubone H, Mathew O P, Sant'Ambrogio G
Respir Physiol. 1987 Aug;69(2):195-207. doi: 10.1016/0034-5687(87)90027-2.
We studied the respiratory modulation of laryngeal afferents and their response to transmural pressure in 24 anesthetized, spontaneously breathing rabbits. Laryngeal afferent activity has a predominant inspiratory augmentation during tracheal breathing or tracheal occlusion that can be accounted for by the respiratory movement transmitted to the larynx through the trachea. During upper airway breathing or upper airway occlusion SLN afferent activity increases in expiration and decreases in inspiration. This respiratory modulation is due to changes in upper airway pressure (Pua). In fact, positive pressure stimulates SLN afferent activity, while negative pressure inhibits it. Mechanical restriction of epiglottal movement reduced the response to Pua changes during upper airway occlusion and application of maintained positive (0.1-0.5 kPa) and negative (-0.1 to -0.5 kPa) pressures (P less than 0.005). Furthermore, surgical removal of epiglottis decreased the baseline activity of SLN to 16.5% of control. These experiments suggest that in the rabbit the epiglottis is the main source of SLN afferent activity and that its displacement, due to changes in Pua, is the most important factor for modulating SLN activity. Most of the laryngeal receptors showed an inspiratory augmentation with tracheal breathing and occlusion, were stimulated by positive pressure and inhibited by negative pressure, reflecting the behavior observed in the whole nerve.
我们在24只麻醉状态下自主呼吸的家兔中研究了喉传入神经的呼吸调制及其对跨壁压的反应。在气管呼吸或气管阻塞期间，喉传入神经活动在吸气时显著增强，这可由通过气管传递至喉部的呼吸运动来解释。在上气道呼吸或上气道阻塞期间，喉上神经（SLN）传入神经活动在呼气时增加，在吸气时减少。这种呼吸调制是由于上气道压力（Pua）的变化所致。事实上，正压刺激SLN传入神经活动，而负压则抑制它。会厌运动的机械限制减少了在上气道阻塞期间以及施加持续正压（0.1 - 0.5 kPa）和负压（-0.1至-0.5 kPa）时对Pua变化的反应（P < 0.005）。此外，手术切除会厌使SLN的基线活动降至对照的16.5%。这些实验表明，在家兔中会厌是SLN传入神经活动的主要来源，并且由于Pua变化导致的其移位是调节SLN活动的最重要因素。大多数喉感受器在气管呼吸和阻塞时表现出吸气增强，受到正压刺激并被负压抑制，这反映了在整个神经中观察到的行为。
