Sant'Ambrogio G, Mathew O P, Sant'Ambrogio F B
Respir Physiol. 1985 Sep;61(3):289-300. doi: 10.1016/0034-5687(85)90072-6.
Recording from the superior laryngeal nerve discloses a respiratory modulated activity even in the absence of airflow and pressure changes in the larynx. The present study evaluates the relative contribution of intrinsic laryngeal muscle activity and transmitted tracheal movement on the respiratory modulation of laryngeal mechanoreceptors. Seventy-four receptors were studied in 22 anesthetized spontaneously breathing dogs. The modulation of 31 receptors depended solely on laryngeal muscle activity since it was abolished by cold block of laryngeal nerves. Twelve receptors were primarily activated by tracheal movement since tracheal stabilization alone reduced or abolished their modulation. The respiratory modulation of the remaining 31 receptors was found to be dependent on both laryngeal muscle activity and tracheal movements. Lidocaine (2%) was applied to the receptor field of 13 endings; the results indicate that while some receptors are located superficially (blocked within 1 min) others are located in deeper structures (not affected in 30 min). These receptors may be involved in the precise coordination of laryngeal muscle activity and could play a role in the regulation of breathing pattern and airway patency due to their pressure sensitivity.
即使在喉部没有气流和压力变化的情况下，对上喉神经进行记录也能揭示一种呼吸调制活动。本研究评估了喉内肌活动和传导的气管运动对喉机械感受器呼吸调制的相对贡献。在22只麻醉后自主呼吸的犬中对74个感受器进行了研究。31个感受器的调制仅取决于喉肌活动，因为喉神经冷阻滞可消除这种调制。12个感受器主要由气管运动激活，因为仅气管稳定就可减少或消除它们的调制。发现其余31个感受器的呼吸调制取决于喉肌活动和气管运动。将2%的利多卡因应用于13个末梢的感受器区域；结果表明，一些感受器位于浅表部位（1分钟内被阻滞），而另一些位于更深的结构中（30分钟内未受影响）。这些感受器可能参与喉肌活动的精确协调，并且由于它们的压力敏感性，可能在呼吸模式调节和气道通畅中发挥作用。
