Peris María Paz, Ortega-Hernández Paula, Morales Mariano, Castillo Juan Antonio, Moreno Bernardino
Animal Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, 50009 Zaragoza, Spain.
Animals (Basel). 2022 Oct 15;12(20):2784. doi: 10.3390/ani12202784.
Pathological characteristics are well described in canine leishmaniosis (CanL). However, atypical lesions that can be confused with other pathologies or trigger unusual clinical signs are sporadically reported. Atypical lesions were observed during routine postmortem examination in three -infected dogs and samples were taken for histopathological and immunohistochemical studies. Clinical signs, biochemical parameters, level of antibodies, and parasite detection by PCR were also evaluated. Atypical lesions were found in the peritoneal cavity, liver, and spleen. Splenomegalia and hepatomegalia were observed in all dogs. In addition, multifocal dark to white nodules of variable size were observed in the peritoneal cavity, liver, and spleen of one dog and in the spleen of the other two dogs. One dog presented diffuse irregular whitish lines with a threadlike appearance and another an intense fibrotic depression in the intermediate lobe. Microscopically, an intense granulomatous inflammation with abundant macrophages, a variable number of lymphocytes, and a low to moderate number of parasites was observed. This study represents the first description of granulomatous peritonitis associated with in dogs. It also shows atypical macroscopic expression of hepatitis in CanL. In the absence of an adequate clinical history and laboratory analyses, certain lesions observed in CanL could admit alternative diagnoses.
犬利什曼病（CanL）的病理特征已有详尽描述。然而，偶有报告称出现了可与其他病症相混淆或引发异常临床症状的非典型病变。在对三只感染犬进行常规尸检期间观察到了非典型病变，并采集样本进行组织病理学和免疫组织化学研究。还评估了临床症状、生化参数、抗体水平以及通过聚合酶链反应（PCR）检测寄生虫的情况。在腹腔、肝脏和脾脏中发现了非典型病变。所有犬均观察到脾肿大和肝肿大。此外，在一只犬的腹腔、肝脏和脾脏以及另外两只犬的脾脏中观察到了大小不一的多灶性深色至白色结节。一只犬呈现出弥漫性不规则白色线状且呈丝状外观，另一只犬中叶出现强烈的纤维化凹陷。显微镜下观察到强烈的肉芽肿性炎症，有大量巨噬细胞、数量不等的淋巴细胞以及少量至中等数量的寄生虫。本研究首次描述了犬中与[此处原文可能缺失信息]相关的肉芽肿性腹膜炎。它还显示了犬利什曼病中肝炎的非典型宏观表现。在缺乏充分临床病史和实验室分析的情况下，犬利什曼病中观察到的某些病变可能会有其他诊断结果。
