（西氏威氏木）奥氏伯格木和（格氏木）DC.（桃金娘科）精油的植物化学特征、初步毒性及抗氧化能力
Phytochemical Profile, Preliminary Toxicity, and Antioxidant Capacity of the Essential Oils of (H. West ex Willd.) O. Berg. and (G. Mey) DC. (Myrtaceae).
作者信息
de Moraes Ângelo Antônio Barbosa, Ferreira Oberdan Oliveira, da Costa Leonardo Souza, Almeida Lorena Queiroz, Varela Everton Luiz Pompeu, Cascaes Márcia Moraes, de Jesus Pereira Franco Celeste, Percário Sandro, Nascimento Lidiane Diniz do, de Oliveira Mozaniel Santana, Andrade Eloisa Helena de Aguiar
机构信息
Faculdade de Engenharia Química, Instituto de Tecnologia, Universidade Federal do Pará, Rua Augusto Corrêa, 01, Guamá, Belém 66075-900, Brazil.
Laboratório Adolpho Ducke, Coordenação de Botânica, Museu Paraense Emílio Goeldi, Av. Perimetral, 1901, Terra Firme, Belém 66077-830, Brazil.
出版信息
Antioxidants (Basel). 2022 Oct 21;11(10):2076. doi: 10.3390/antiox11102076.
The essential oils (EOs) of Myrciaria floribunda (Mflo) and Myrcia sylvatica (Msyl) (Myrtaceae) were obtained by hydrodistillation. The analysis of volatile constituents was performed by GC/MS. Preliminary toxicity was assessed on Artemia salina Leach. The antioxidant capacity was measured by the ABTS•+ and DPPH• radical inhibitory activities. The results indicate that the Mflo EO had the highest yield (1.02%), and its chemical profile was characterized by high levels of hydrocarbon (65.83%) and oxygenated (25.74%) monoterpenes, especially 1,8-cineole (23.30%), terpinolene (22.23%) and α-phellandrene (22.19%). Regarding the Msyl EO, only hydrocarbon (51.60%) and oxygenated (46.52%) sesquiterpenes were identified in the sample, with (Z)-α-trans-bergamotene (24.57%), α-sinensal (13.44%), and (Z)-α-bisabolene (8.33%) at higher levels. The EO of Mflo exhibited moderate toxicity against A. salina (LC50 = 82.96 ± 5.20 µg.mL−1), while the EO of Msyl was classified as highly toxic (LC50 = 2.74 ± 0.50 µg.mL−1). In addition, relative to Trolox, the EOs of Mflo and Msyl showed significant inhibitory effects (p < 0.0001) against the DPPH• radical. This study contributes to the expansion of chemical and biological knowledge on the EOs of Myrtaceae species from the Amazon region.
通过水蒸馏法获得了多花番樱桃（Myrciaria floribunda，Mflo）和森林番樱桃（Myrcia sylvatica，Msyl）（桃金娘科）的精油。采用气相色谱/质谱联用仪（GC/MS）对挥发性成分进行分析。以卤虫（Artemia salina Leach）为实验对象评估初步毒性。通过ABTS•+和DPPH•自由基抑制活性测定抗氧化能力。结果表明，Mflo精油的产率最高（1.02%），其化学组成以高水平的烃类（65.83%）和含氧单萜（25.74%）为特征，尤其是1,8-桉叶素（23.30%）、萜品油烯（22.23%）和α-水芹烯（22.19%）。关于Msyl精油，样品中仅鉴定出烃类（51.60%）和含氧倍半萜（46.52%），其中（Z）-α-反式佛手柑烯（24.57%）、α-辛醛（13.44%）和（Z）-α-红没药烯（8.33%）含量较高。Mflo精油对卤虫表现出中等毒性（LC50 = 82.96 ± 5.20 µg.mL−1），而Msyl精油被归类为高毒性（LC50 = 2.74 ± 0.50 µg.mL−1）。此外，相对于Trolox，Mflo和Msyl的精油对DPPH•自由基表现出显著的抑制作用（p < 0.0001）。本研究有助于拓展对亚马逊地区桃金娘科植物精油的化学和生物学知识。
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