睡眠期间呼吸改变对阻塞性睡眠呼吸暂停（OSA）合并症的影响
The Burden of Respiratory Alterations during Sleep on Comorbidities in Obstructive Sleep Apnoea (OSA).
作者信息
Tondo Pasquale, Fanfulla Francesco, Scioscia Giulia, Sabato Roberto, Salvemini Michela, De Pace Cosimo C, Foschino Barbaro Maria Pia, Lacedonia Donato
机构信息
Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Respiratory and Intensive Care Unit, Department of Specialistic Medicine, "Policlinico Foggia" University Hospital, 71122 Foggia, Italy.
出版信息
Brain Sci. 2022 Oct 6;12(10):1359. doi: 10.3390/brainsci12101359.
BACKGROUND
Obstructive sleep apnoea (OSA) has an important impact on the risk of morbidity and mortality, so we have designed the present study to understand which factor is most involved in the risk of developing a comorbidity between OSA severity and nocturnal hypoxemia.
METHODS
A retrospective study was conducted on 617 adult subjects who were referred to our unit for a suspicion of OSA between January 2018 and January 2020.
RESULTS
Sleep investigations performed by participants (72% male and obese in 70% of cases) reported an overall mean apnoea-hypopnoea index (AHI) of 44.0 ± 24.8 events·h. Overall, 66% were classified as severe OSA and 76% experienced nocturnal hypoxemia. By analysing the burden of OSA severity and nocturnal hypoxemia on the comorbidities risk, multivariate analysis highlighted the predominant role of age and obesity. Accordingly, after the exclusion of the older and obese participants from the analyses, we noticed that severe OSA was related to the risk of hypertension (odds ratio (OR) = 3.0 [95% confidence interval [CI] 1.4-6.2], = 0.004) as well as nocturnal hypoxemia (OR = 2.6 [95% CI 1.2-5.4], = 0.01).
CONCLUSIONS
The study seems to suggest that in young, non-obese subjects, OSA is a predisposing factor for the risk of developing hypertension.
背景
阻塞性睡眠呼吸暂停（OSA）对发病和死亡风险有重要影响，因此我们设计了本研究，以了解哪个因素与OSA严重程度和夜间低氧血症之间合并症发生风险的关联最为密切。
方法
对2018年1月至2020年1月期间因疑似OSA转诊至我们科室的617名成年受试者进行了一项回顾性研究。
结果
参与者（72%为男性，70%的病例为肥胖）进行的睡眠调查显示，总体平均呼吸暂停低通气指数（AHI）为44.0±24.8次/小时。总体而言，66%被归类为重度OSA，76%经历夜间低氧血症。通过分析OSA严重程度和夜间低氧血症对合并症风险的影响，多变量分析突出了年龄和肥胖的主要作用。因此，在分析中排除年龄较大和肥胖的参与者后，我们注意到重度OSA与高血压风险相关（比值比（OR）=3.0[95%置信区间[CI]1.4 - 6.2]，P = 0.004）以及夜间低氧血症（OR = 2.6[95%CI 1.2 - 5.4]，P = 0.01）。
结论
该研究似乎表明，在年轻、非肥胖的受试者中，OSA是发生高血压风险的一个诱发因素。
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