Sleep Medicine Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Scientific Institute of Pavia, Pavia 27100, Italy.
Pulmonary and Sleep Medicine, University of Washington, Seattle Children's Hospital, Seattle, WA 98105, USA.
Sleep Med Rev. 2021 Apr;56:101409. doi: 10.1016/j.smrv.2020.101409. Epub 2020 Nov 28.
A bidirectional connection between sleep and cancer exists; however, the specific associations between individual sleep disorders and particular tumors are not very clear. An accurate assessment of sleep disorders in cancer patients is necessary to improve patient health, survival, response to therapy, quality of life, reduction of comorbidities/complications. Indeed, recent scientific evidence shows that knowledge and management of sleep disorders offer interesting therapeutic perspectives for the treatment of cancer. In light of this need, the objective of this review is to assess the evidence highlighted in the research of the last ten years on the correlation between each specific category of sleep disorder according to the International Classification of Sleep Disorders 3rd Ed. and several types of tumor based on their anatomical location (head-neck, including the brain and thyroid; lung; breast; ovary; endometrium; testes; prostate; bladder; kidney; gastrointestinal tract, subdivided into: stomach, liver, colon, pancreas; skin; bone tumors; hematological malignancies: leukemia, lymphoma, multiple myeloma, polycythemia), in order to evaluate what is currently known about: 1) sleep disorders as cancer risk factor; 2) tumors associated with the onset of sleep disorders; 3) targeted therapies of sleep disorders in cancer patients and new oncological perspectives following the evaluation of sleep.
睡眠与癌症之间存在双向关联；然而，个别睡眠障碍与特定肿瘤之间的具体关联尚不清楚。准确评估癌症患者的睡眠障碍对于改善患者健康、生存、对治疗的反应、生活质量、减少合并症/并发症是必要的。事实上，最近的科学证据表明，睡眠障碍的知识和管理为癌症的治疗提供了有趣的治疗前景。有鉴于此，本综述的目的是评估过去十年中根据国际睡眠障碍分类第 3 版（International Classification of Sleep Disorders 3rd Ed.）对每一种特定类别的睡眠障碍与几种肿瘤之间相关性的研究中所强调的证据，这些肿瘤根据其解剖位置（头颈部，包括大脑和甲状腺；肺部；乳房；卵巢；子宫内膜；睾丸；前列腺；膀胱；肾脏；胃肠道，分为：胃、肝、结肠、胰腺；皮肤；骨肿瘤；血液恶性肿瘤：白血病、淋巴瘤、多发性骨髓瘤、红细胞增多症）进行分类，以评估目前已知的情况：1）睡眠障碍作为癌症的风险因素；2）与睡眠障碍相关的肿瘤；3）癌症患者睡眠障碍的靶向治疗以及在评估睡眠之后的新肿瘤学观点。
