Wright Kim, Mostazir Mohammod, Bailey Ella, Dunn Barnaby D, O'Mahen Heather, Sibsey Michaela, Thomas Zoe
Department of Psychology, University of Exeter, Perry Road, Exeter EX4 4QG, UK.
Department of Psychology, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Brain Sci. 2022 Oct 19;12(10):1407. doi: 10.3390/brainsci12101407.
Behavioural Activation (BA) is associated with a substantial evidence base for treatment of acute unipolar depression, and has promise as an easily disseminable psychological intervention for bipolar depression. Using a randomised multiple baseline case series design we examined the feasibility and acceptability of an adapted version of BA in a U.K. outpatient sample of 12 adults with acute bipolar depression. Participants were allocated at random to a 3-8 week wait period before being offered up to 20 sessions of BA. They completed outcome measures at intake, pre- and post-treatment and weekly symptom measures across the study period. Retention in therapy was high (11/12 participants completed the target minimum number of sessions), and all participants returning acceptability measures reported high levels of satisfaction with the intervention. No therapy-related serious adverse events were reported, nor were there exacerbations in manic symptoms that were judged to be a result of the intervention. The pattern of change on outcome measures is consistent with the potential for clinical benefit; six of the nine participants with a stable baseline showed clinically significant improvement on the primary outcome measure. The findings suggest adapted BA for bipolar depression is a feasible and acceptable approach that merits further investigation.
行为激活疗法（BA）在治疗急性单相抑郁症方面有大量证据支持，并且有望成为一种易于传播的双相抑郁症心理干预方法。我们采用随机多基线病例系列设计，在英国12名患有急性双相抑郁症的门诊成人样本中，研究了改编版BA的可行性和可接受性。参与者被随机分配到3至8周的等待期，之后接受最多20次BA治疗。他们在入组时、治疗前和治疗后完成了结局测量，并在整个研究期间每周进行症状测量。治疗保留率很高（12名参与者中有11名完成了目标最少治疗次数），所有返回可接受性测量的参与者都报告对干预措施高度满意。未报告与治疗相关的严重不良事件，也没有因干预导致的躁狂症状加重。结局测量的变化模式与临床获益的可能性一致；9名基线稳定的参与者中有6名在主要结局测量上显示出临床显著改善。研究结果表明，改编版BA治疗双相抑郁症是一种可行且可接受的方法，值得进一步研究。
