Adaptative Supramolecular Nanosystems Group, Institut Europeen des Membranes, University of Montpellier, ENSCM-CNRS, Place E. Bataillon CC047, 34095 Montpellier, France.
Biomolecules. 2022 Oct 13;12(10):1473. doi: 10.3390/biom12101473.
One of the most common biochemical processes is the proton transfer through the cell membranes, having significant physiological functions in living organisms. The proton translocation mechanism has been extensively studied; however, mechanistic details of this transport are still needed. During the last decades, the field of artificial proton channels has been in continuous growth, and understanding the phenomena of how confined water and channel components mediate proton dynamics is very important. Thus, proton transfer continues to be an active area of experimental and theoretical investigations, and acquiring insights into the proton transfer mechanism is important as this enlightenment will provide direct applications in several fields. In this review, we present an overview of the development of various artificial proton channels, focusing mostly on their design, self-assembly behavior, proton transport activity performed on bilayer membranes, and comparison with protein proton channels. In the end, we discuss their potential applications as well as future development and perspectives.
最常见的生化过程之一是质子穿过细胞膜的转移，这在生物体中具有重要的生理功能。质子迁移机制已经得到了广泛的研究；然而，这种传输的机械细节仍有待研究。在过去的几十年中，人工质子通道领域一直在不断发展，理解受限水和通道成分如何介导质子动力学的现象非常重要。因此，质子转移仍然是实验和理论研究的活跃领域，深入了解质子转移机制很重要，因为这一启示将为多个领域提供直接的应用。在这篇综述中，我们介绍了各种人工质子通道的发展概况，主要集中在它们的设计、自组装行为、在双层膜上的质子传输活性以及与蛋白质质子通道的比较。最后，我们讨论了它们作为潜在应用的未来发展和前景。
