Department of Chemistry, Fudan University, Shanghai, China.
State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, China.
J Am Chem Soc. 2020 Sep 16;142(37):15638-15643. doi: 10.1021/jacs.0c00601. Epub 2020 Sep 3.
Artificial aquaporins are synthetic molecules that mimic the structure and function of natural aquaporins (AQPs) in cell membranes. The development of artificial aquaporins would provide an alternative strategy for treatment of AQP-related diseases. In this report, an artificial aquaporin has been constructed from an amino-terminated tubular molecule, which operates in a unimolecular mechanism. The artificial channel can work in cell membranes with high water permeability and selectivity rivaling those of AQPs. Importantly, the channel can restore wound healing of the cells that contain function-lost AQPs.
人工水通道蛋白是模拟细胞膜中天然水通道蛋白 (AQP) 结构和功能的合成分子。人工水通道蛋白的开发为治疗 AQP 相关疾病提供了一种替代策略。在本报告中，构建了一种由氨基封端的管状分子组成的人工水通道蛋白，该水通道蛋白以单分子机制运行。人工通道在细胞膜中具有高水透过率和选择性，可与 AQP 相媲美。重要的是，该通道可以恢复含有功能丧失 AQP 的细胞的伤口愈合。
