Woods S J, Saron M F, Pfau C J
Scand J Immunol. 1987 Aug;26(2):97-103. doi: 10.1111/j.1365-3083.1987.tb02241.x.
Intracerebral (i.c.) infection of adult mice with lymphocytic choriomeningitis (LCM) virus can result in acute lethal central nervous system (CNS) disease which is the result of the host's thymus-derived lymphocyte (T cell) response against the virus. Whether the specific effector function of the T cell is that of a cytotoxic cell (Tc) or a delayed-type hypersensitivity cell (Td) is still under debate. We assumed that if Td cells were important in pathogenesis then accessory cells in the brain (specifically, glass-adherent macrophages) might vary with the outcome of i.c. infection. We found that accumulation of macrophages in the brain (washed from meninges and skull cap) appeared to be independent of the severity of the infection (controlled by the mouse strain as well as the strain and dose of virus used). However, differentiation of macrophages was clearly linked to whether or not the infection caused rapid death. In mice that were destined to survive, macrophages became large, extensively vacuolated, and phagocytically active. In lethally-infected mice macrophages were small and had poor phagocytic abilities. At present this dichotomy could be viewed as either a cause or a consequence of disease outcome. However, the data are not inconsistent with the hypothesis that Td lymphocytes may be of primary importance in pathogenesis.
用淋巴细胞性脉络丛脑膜炎（LCM）病毒对成年小鼠进行脑内（i.c.）感染，可导致急性致死性中枢神经系统（CNS）疾病，这是宿主胸腺来源的淋巴细胞（T细胞）对病毒产生反应的结果。T细胞的特异性效应功能是细胞毒性细胞（Tc）还是迟发型超敏反应细胞（Td）仍存在争议。我们假设，如果Td细胞在发病机制中起重要作用，那么脑中的辅助细胞（特别是玻璃黏附巨噬细胞）可能会因脑内感染的结果而有所不同。我们发现，脑中（从脑膜和头盖骨冲洗得到）巨噬细胞的积聚似乎与感染的严重程度无关（感染严重程度由小鼠品系以及所用病毒的品系和剂量控制）。然而，巨噬细胞的分化显然与感染是否导致快速死亡有关。在存活的小鼠中，巨噬细胞变大，出现广泛的空泡化，且吞噬活性增强。在致死性感染的小鼠中，巨噬细胞较小且吞噬能力较差。目前，这种二分法可被视为疾病结果的原因或后果。然而，这些数据与Td淋巴细胞可能在发病机制中起主要作用的假说并不矛盾。
