Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Int J Mol Sci. 2022 Oct 14;23(20):12312. doi: 10.3390/ijms232012312.
Idiopathic nephrotic syndrome (INS) is a chronic disease affecting children in early childhood. It is characterized by proteinuria, hypoalbuminemia, edema and hyperlipidemia. To date, the diagnosis is usually established at an advanced stage of proteinuria. Therefore, new methods of early INS detection are desired. This study was designed to assess brain-derived neurotrophic factor (BDNF) as a potential marker in the early diagnosis of INS. The study group included patients with a diagnosis of idiopathic nephrotic syndrome ( = 30) hospitalized in Clinical Hospital No. 1 in Zabrze, from December 2019 to December 2021. Our study shows that serum BDNF concentration decreased and urine BDNF concentration increased in a group of patients with INS, compared with healthy controls. Such outcomes might be related to loss of the BDNF contribution in podocyte structure maintenance. Moreover, we anticipate the role of BDNF in urine protein concentration increase, which could be used as a direct predictor of urine protein fluctuations in clinical practice. Moreover, the ROC curve has also shown that serum BDNF and urine BDNF levels might be useful as an INS marker.
特发性肾病综合征 (INS) 是一种影响儿童早期的慢性疾病。其特征是蛋白尿、低白蛋白血症、水肿和高脂血症。迄今为止，该诊断通常在蛋白尿的晚期阶段确立。因此，需要新的 INS 早期检测方法。本研究旨在评估脑源性神经营养因子 (BDNF) 作为 INS 早期诊断的潜在标志物。研究组包括 2019 年 12 月至 2021 年 12 月期间在扎布热临床医院 1 号住院的特发性肾病综合征患者（=30）。我们的研究表明，与健康对照组相比，一组 INS 患者的血清 BDNF 浓度降低，尿 BDNF 浓度升高。这种结果可能与足细胞结构维持中 BDNF 贡献的丧失有关。此外，我们预期 BDNF 在尿蛋白浓度增加中的作用，它可作为临床实践中尿蛋白波动的直接预测因子。此外，ROC 曲线也表明，血清 BDNF 和尿 BDNF 水平可能可用作 INS 标志物。
