Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, Poland.
Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze-Rokitnica, Poland.
Int J Mol Sci. 2023 Apr 10;24(8):6993. doi: 10.3390/ijms24086993.
Idiopathic nephrotic syndrome (INS) is a chronic glomerular disease in children, characterized by severe proteinuria, hypoalbuminemia, and/or presence of edema and hyperlipidemia. The pathogenesis, however, has not been yet established. The clinical course of the disease is characterized by frequent relapses. Interleukin-15 (IL-15) is a pro-inflammatory cytokine, that apart from its involvement in the immune system, was found to be playing a vital role in various cells' functioning, including renal tissue. It is desirable to look for new predictors of INS. Our study aimed to evaluate IL-15 as a potential marker in the early diagnosis of the disease. The cohort participating in the study consisted of patients hospitalized in Clinical Hospital No. 1 in Zabrze, from December 2019 to December 2021, including study group with INS ( = 30) and control group ( = 44). Results: The concentration of IL-15 in both serum and urine was significantly elevated in patients with INS, compared to healthy controls. The cytokine might serve as a marker of the disease, however, further research on larger study groups is needed.
特发性肾病综合征（INS）是儿童慢性肾小球疾病，其特征为严重蛋白尿、低白蛋白血症和/或水肿和高脂血症。然而，其发病机制尚未确定。该疾病的临床病程以频繁复发为特征。白细胞介素-15（IL-15）是一种促炎细胞因子，除了参与免疫系统外，还被发现对包括肾脏组织在内的各种细胞的功能起着至关重要的作用。寻找 INS 的新预测因子是可取的。我们的研究旨在评估 IL-15 作为该疾病早期诊断的潜在标志物。参与研究的队列包括 2019 年 12 月至 2021 年 12 月在扎布热临床医院 1 号住院的患者，包括 INS 研究组（=30）和对照组（=44）。结果：与健康对照组相比，INS 患者血清和尿液中的 IL-15 浓度显著升高。该细胞因子可能是疾病的标志物，但需要对更大的研究组进行进一步研究。
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