Gheorghe Roxana-Olimpia, Grosu Andreea Violeta, Bica-Popi Melania, Ristoiu Violeta
Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, District 5, 050095 Bucharest, Romania.
Int J Mol Sci. 2022 Oct 16;23(20):12389. doi: 10.3390/ijms232012389.
Traumatic peripheral neuropathic pain is a complex syndrome caused by a primary lesion or dysfunction of the peripheral nervous system. Secondary to the lesion, resident or infiltrating macrophages proliferate and initiate a cross-talk with the sensory neurons, at the level of peripheral nerves and sensory ganglia. The neuron-macrophage interaction, which starts very early after the lesion, is very important for promoting pain development and for initiating changes that will facilitate the chronicization of pain, but it also has the potential to facilitate the resolution of injury-induced changes and, consequently, promote the reduction of pain. This review is an overview of the unique characteristics of nerve-associated macrophages in the peripheral nerves and sensory ganglia and of the molecules and signaling pathways involved in the neuro-immune cross-talk after a traumatic lesion, with the final aim of better understanding how the balance between pro- and anti-nociceptive dialogue between neurons and macrophages may be modulated for new therapeutic approaches.
创伤性周围神经性疼痛是一种由周围神经系统原发性损伤或功能障碍引起的复杂综合征。继损伤之后，驻留或浸润的巨噬细胞增殖，并在外周神经和感觉神经节水平与感觉神经元启动相互作用。损伤后很早就开始的神经元 - 巨噬细胞相互作用，对于促进疼痛发展和启动有助于疼痛慢性化的变化非常重要，但它也有可能促进损伤诱导变化的消退，从而促进疼痛减轻。本综述概述了外周神经和感觉神经节中与神经相关的巨噬细胞的独特特征，以及创伤性损伤后神经免疫相互作用中涉及的分子和信号通路，最终目的是更好地理解如何调节神经元和巨噬细胞之间促伤害性和抗伤害性对话的平衡，以探索新的治疗方法。
