Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Pediatric Cardiac Surgery Department, Poznan University of Medical Sciences, 60-572 Poznan, Poland.
Int J Mol Sci. 2022 Oct 17;23(20):12409. doi: 10.3390/ijms232012409.
Neutrophils play a significant role in immune and inflammatory reactions. The preoperative inflammatory activation may have a detrimental effect on postoperative outcomes. The aim of the study was to investigate the relation between preoperative hematological indices on postoperative complications’ risk in pediatric cardiac congenital surgery. The retrospective single center analysis included 93 pediatric patients (48 (65%) males and 45 (35%) females), mean age of 7 (3−30) months referred for cardiac surgery in cardiopulmonary bypass due to functional single ventricle disease (26 procedures), shunts lesions (40 procedures) and cyanotic disease (27 procedures). Among simple hematological indices, the receiver-operating-characteristic curve showed that a neutrophil count below 2.59 K/uL was found as an optimal cut-off point for predicting postoperative atrioventricular block following pediatric cardiac surgery (AUC = 0.845, p < 0.0001) yielding a sensitivity of 100% and a specificity of 65.62%. Preoperative values of neutrophil count below 2.59 K/uL in whole blood analysis can be regarded as a predictive factor (AUC = 0.845, p < 0.0001) for postoperative atrioventricular block in pediatric cardiac surgery.
中性粒细胞在免疫和炎症反应中发挥重要作用。术前炎症激活可能对术后结果产生不利影响。本研究旨在探讨小儿心脏先天性手术中术前血液学指标与术后并发症风险的关系。这项回顾性单中心分析纳入了 93 名小儿患者(48 名(65%)男性和 45 名(35%)女性),平均年龄为 7(3-30)个月,因功能性单心室疾病(26 例)、分流病变(40 例)和紫绀性疾病(27 例)在体外循环下心内直视手术。在简单的血液学指标中,受试者工作特征曲线显示,中性粒细胞计数低于 2.59 K/uL 可作为预测小儿心脏手术后房室传导阻滞的最佳截断值(AUC=0.845,p<0.0001),敏感性为 100%,特异性为 65.62%。全血分析中术前中性粒细胞计数低于 2.59 K/uL 可视为小儿心脏手术术后房室传导阻滞的预测因素(AUC=0.845,p<0.0001)。