School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Infection Control, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Int J Environ Res Public Health. 2022 Oct 11;19(20):13006. doi: 10.3390/ijerph192013006.
Since the advent of 2019 novel coronavirus (COVID-19), the coexistence between social stigma and depression symptoms (depression hereafter) in COVID-19 patients has been mentioned, but the mechanisms involved remains unclear. This study aimed to explore how the stigma affects depression during the mid-pandemic period.
A cross-sectional survey using non-probability sampling was conducted among asymptomatic COVID-19 carriers in Shanghai, China (April 2022). An online questionnaire was used to obtain information on demographic characteristics and psychological traits. Logistic regression and path analysis were performed to analyze the depression risk factors and examine the mediation model, respectively.
A total of 1283 participants (59.6% men) were involved in this study, in which 44.7% of carriers reported having depression. Univariate analyses found that education level (OR 0.575; 95% CI 0.448-0.737) and doses of vaccine (OR 1.693; 95% CI 1.042-2.750), were significantly associated with depression among asymptomatic carriers. The association between social stigma and depression was fully mediated by their feelings of entrapment and decadence (indirect effect = 0.204, < 0.001; direct effect = -0.059, = 0.058). The mediating role of entrapment between stigma and depression was moderated by age group (estimate = 0.116, = 0.008).
Mental health issues resulting from the COVID-19 pandemic are increasingly apparent in China and require urgent attention and responses. These findings provide new perspectives for the early prevention of depression in asymptomatic carriers.
自 2019 年新型冠状病毒（COVID-19）出现以来，COVID-19 患者中社会污名与抑郁症状（下文简称抑郁）共存的现象已被提及，但其中涉及的机制尚不清楚。本研究旨在探索在大流行中期，污名是如何影响抑郁的。
本研究采用非概率抽样，于 2022 年 4 月在中国上海对无症状 COVID-19 携带者进行了横断面调查。采用在线问卷收集人口统计学特征和心理特征信息。分别采用 logistic 回归和路径分析来分析抑郁的风险因素，并检验中介模型。
本研究共纳入 1283 名参与者（59.6%为男性），其中 44.7%的携带者报告存在抑郁。单因素分析发现，教育水平（OR 0.575；95%CI 0.448-0.737）和疫苗接种剂量（OR 1.693；95%CI 1.042-2.750）与无症状携带者的抑郁显著相关。社会污名与抑郁之间的关系完全通过他们的束缚感和颓废感（间接效应=0.204， < 0.001；直接效应=-0.059， = 0.058）进行中介。污名与抑郁之间的中介作用受到年龄组的调节（估计值=0.116， = 0.008）。
中国 COVID-19 大流行期间的心理健康问题日益明显，需要紧急关注和应对。这些发现为无症状携带者早期预防抑郁提供了新视角。
