Department of Ophthalmology, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan.
Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Int J Environ Res Public Health. 2022 Oct 12;19(20):13108. doi: 10.3390/ijerph192013108.
This cohort study aimed to research the correlation between endophthalmitis and stroke development in ankylosing spondylitis (AS) patients by reviewing National Health Insurance Research Database (NHIRD) data.
This study obtained data from the NHIRD over a sixteen-year period. The primary outcome was stroke development. We used Fisher's exact test and Pearson's chi-squared test to analyze the variables. We investigated the risk factors for disease development using Cox regression analyses. We compared the cumulative incidence of stroke using Kaplan-Meier analysis.
The study cohort included 549 patients with AS and endophthalmitis, while the comparison cohort included 2196 patients with AS but without endophthalmitis. The stroke development was increased in the study cohort (adjusted hazard ratio, 1.873; ≤ 0.001). The total stroke development in the study cohort and the comparison cohort was 1724.44 per 100,000 person-years and 1085.11 per 100,000 person-years, respectively (adjusted hazard ratio, 1.873; 95% confidence interval, 1.776-2.022; < 0.001). Our study cohort showed an increased stroke rate.
Our studies showed that endophthalmitis increases the risk of stroke in AS patients and endophthalmitis is an independent risk factor for stroke in AS patients. Nonetheless, advanced studies that thoroughly investigate the correlation between endophthalmitis and stroke in AS patients are needed to validate our findings.
本队列研究旨在通过回顾国家健康保险研究数据库（NHIRD）的数据，研究强直性脊柱炎（AS）患者眼内炎与中风发展之间的相关性。
本研究从 NHIRD 获得了超过 16 年的数据。主要结局是中风的发生。我们使用 Fisher 确切检验和 Pearson χ2 检验分析变量。我们使用 Cox 回归分析调查疾病发展的风险因素。我们使用 Kaplan-Meier 分析比较中风的累积发生率。
研究队列包括 549 例 AS 伴眼内炎患者，而对照组包括 2196 例 AS 但无眼内炎患者。研究队列中风的发生风险增加（调整后的危险比，1.873； ≤ 0.001）。研究队列和对照组的总中风发生率分别为每 100,000 人年 1724.44 例和每 100,000 人年 1085.11 例（调整后的危险比，1.873；95%置信区间，1.776-2.022； < 0.001）。我们的研究队列显示中风发生率增加。
我们的研究表明，眼内炎会增加 AS 患者中风的风险，眼内炎是 AS 患者中风的独立危险因素。然而，需要更深入研究 AS 患者眼内炎与中风之间相关性的高级研究来验证我们的发现。
