Health literacy measurement is important to improve equity, health and well-being as part of health system transformation. However, health literacy data of good quality are often lacking or difficult to access for decision-makers. To better inform policy, research and practice, this paper discusses how to move from project-based health literacy data and measurement to an integrated system of analytics and insights enhancing data-driven value creation in health-literate organizations. There is a need for the development of health literacy data pipelines, data dashboards, and data governance mechanisms which are timely and trustworthy. Investing in health literacy data analytics and data governance can pave the way for the integration of health literacy as an acknowledged global health indicator in large-scale surveys, ventures, and daily business. Leadership and management buy-in are needed to steer the process. Lessons learned from decades of measurement research combined with strategic implementation of systematic use of health literacy monitoring may accelerate the progress.