Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.
Auckland District Health Board, Auckland 1051, New Zealand.
Int J Environ Res Public Health. 2022 Oct 18;19(20):13459. doi: 10.3390/ijerph192013459.
The aim of this paper is to systematically review the literature to determine whether early childhood caries (ECC) is significantly associated with caries development in permanent teeth among school children and adolescents, and to identify the association of other risk factors over 24 months. A systematic literature search was performed in four electronic databases and via a manual search from inception to 28 July 2022. Independent study selection and screening, data extraction, evaluation of risk of bias using ROBINS-I tool and certainty of evidence with GRADE were performed. Ten cohort studies were included, all of which identified that ECC significantly increased the risk of caries in permanent teeth. Meta-analysis suggested children with ECC were three times more likely to develop caries in their permanent teeth (OR, 3.22; 95% CI 2.80, 3.71; < 0.001), especially when the lesions were in primary molars and progressed to dentine. However, the certainty of evidence was substantially compromised by serious risk of bias and inconsistency between studies. There were inconsistent findings between socioeconomic or behavioural factors on caries development, which could not be pooled for meta-analyses. ECC significantly increases the likelihood of caries development in permanent teeth. Evidence on the association of socioeconomic and oral health behavioural factors is weak.
本文旨在通过系统综述文献，确定幼儿龋（ECC）是否与学龄儿童和青少年恒齿龋病的发展有显著关联，并确定其他风险因素在 24 个月内的关联。从 2022 年 7 月 28 日开始，我们在四个电子数据库中进行了系统的文献检索，并进行了手动搜索。我们独立进行了研究选择和筛选、数据提取、使用 ROBINS-I 工具评估偏倚风险以及使用 GRADE 评估证据确定性。纳入了 10 项队列研究，所有研究都表明 ECC 显著增加了恒齿龋病的风险。Meta 分析表明，患有 ECC 的儿童发生恒齿龋病的可能性是三倍（OR，3.22；95%CI 2.80，3.71；<0.001），尤其是当病变发生在乳磨牙且进展到牙本质时。然而，由于研究之间存在严重的偏倚风险和不一致性，证据的确定性受到了很大影响。在社会经济或行为因素对龋病发展的影响方面，存在不一致的发现，因此无法进行 Meta 分析。ECC 显著增加了恒齿龋病的发生可能性。关于社会经济和口腔健康行为因素关联的证据较弱。
