Burt J T, Kapp J P, Smith R R
Surg Neurol. 1987 Oct;28(4):265-8. doi: 10.1016/0090-3019(87)90304-1.
The effectiveness of hyperbaric oxygen in reducing the incidence of cerebral infarction during the first 36 hours after occlusion of the right common carotid artery was investigated in gerbils. After carotid ligation, the gerbils were divided into four groups: controls, which breathed air at ambient pressure; group 1, which received hyperbaric oxygen at 1.5 atmospheres absolute pressure (ATA) for 36 hours, with a 5-minute, 1.5-ATA air break each hour; group 2, which received hyperbaric oxygen at 1.5 ATA for 1 hour alternating with 1 hour air at 1 ATA, for 36 hours; and group 3, which received hyperbaric oxygen at 1.5 ATA with hourly 5-minute air breaks for 18 hours, and ambient air for the second 18 hours. Neurological evaluations and staining of the brain with tetrazolium revealed the following results at 36 hours after carotid ligation: 72% of the controls had cerebral infarcts; 26% of the gerbils in group 1 had infarcts, but all animals died at 24-36 hours after beginning hyperbaric oxygen exposure from oxygen toxicity; 44% of the gerbils in group 2 had infarcts; 11% of the gerbils in group 3 had infarcts during the first 18 hours after carotid ligation, and no infarcts developed in the 18 hours that followed. Hyperbaric oxygen reduces the incidence of cerebral infarction after carotid artery ligation, presumably by allowing time for collateral circulation to develop.
在沙鼠中研究了高压氧在减少右颈总动脉闭塞后最初36小时内脑梗死发生率方面的有效性。颈动脉结扎后，沙鼠被分为四组：对照组，在常压下呼吸空气；第1组，在绝对压力1.5个大气压（ATA）下接受36小时高压氧治疗，每小时有5分钟的1.5 ATA空气间歇；第2组，在1.5 ATA下接受1小时高压氧治疗，与1 ATA空气交替1小时，持续36小时；第3组，在1.5 ATA下接受18小时高压氧治疗，每小时有5分钟空气间歇，后18小时呼吸环境空气。神经学评估和用四氮唑对大脑进行染色显示，在颈动脉结扎后36小时有以下结果：72%的对照组出现脑梗死；第1组中26%的沙鼠出现梗死，但所有动物在开始高压氧暴露后24 - 36小时因氧中毒死亡；第2组中44%的沙鼠出现梗死；第3组中11%的沙鼠在颈动脉结扎后的前18小时出现梗死，在随后的18小时内未出现梗死。高压氧可降低颈动脉结扎后脑梗死的发生率，可能是通过为侧支循环的形成留出时间。
