Macioce-Tisdale Nikeya L, Ashbaugh Alan, Hendrix Keeley, Collins Margaret S, Porollo Aleksey, Cushion Melanie T
Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Cincinnati VAMC, Medical Research Service, Cincinnati, OH 45220, USA.
J Fungi (Basel). 2022 Oct 19;8(10):1101. doi: 10.3390/jof8101101.
Many preclinical studies of infectious diseases have neglected experimental designs that evaluate potential differences related to sex with a concomitant over-reliance on male model systems. Hence, the NIH implemented a monitoring system for sex inclusion in preclinical studies.
Per this mandate, we examined the lung burdens of infection in three mouse strains in both male and female animals at early, mid, and late time points.
Females in each strain had higher infection burdens compared to males at the later time points.
Females should be included in experimental models studying spp.
许多传染病的临床前研究忽略了评估与性别相关潜在差异的实验设计，同时过度依赖雄性模型系统。因此，美国国立卫生研究院实施了一项临床前研究中性别纳入情况的监测系统。
根据这项指令，我们在早期、中期和晚期时间点检查了三种小鼠品系的雄性和雌性动物肺部的感染负荷。
在后期时间点，每个品系的雌性动物的感染负荷均高于雄性。
在研究 spp. 的实验模型中应纳入雌性动物。
