Francis D M, Burren C P, Clunie G J
Surgery. 1987 Sep;102(3):485-92.
Evidence suggests that blood transfusions depress immunologic reactivity; as some tumors are influenced by the immune status of their host, it is possible that transfusions could promote tumor growth by impairing host immunity. The influence of blood transfusion on the growth of a transplantable B16 melanoma was examined in nude (athymic) CBA mice and immunocompetent C57 BL/6J mice. Recipients were given infusions of saline solution or syngeneic or H-2-incompatible allogeneic blood transfusions on two occasions 3 days apart. Infusions were begun 10 days before inoculation of a single cell suspension of B16 melanoma. Growth was determined by measurements of primary tumor volume and tumor weight after excision. There was no statistically significant difference in tumor size or weight between the three recipient groups of athymic mice. However, immunocompetent mice given H-2-incompatible allogeneic blood had higher rates of tumor engraftment--saline solution recipients versus allogeneic recipients: chi 2 = 13.2, df = 1, p less than 0.001; syngeneic recipients versus allogeneic recipients: chi 2 = 2.97, df = 1, p greater than 0.05. In the allogeneic group significantly larger and heavier tumors developed than in mice given syngeneic blood or saline solution. The study indicates that H-2-incompatible allogeneic blood transfusions can influence the growth of a transplantable murine tumor by a mechanism that involves a cell-mediated immune response.
有证据表明输血会抑制免疫反应；由于某些肿瘤受其宿主免疫状态的影响，输血有可能通过损害宿主免疫力来促进肿瘤生长。在无胸腺（裸）CBA小鼠和具有免疫活性的C57 BL/6J小鼠中研究了输血对可移植B16黑色素瘤生长的影响。在接种B16黑色素瘤单细胞悬液前10天开始，给受体动物每隔3天输注一次盐溶液、同基因血液或H-2不相合的异基因血液，共输注两次。通过测量切除后的原发性肿瘤体积和肿瘤重量来确定肿瘤生长情况。无胸腺小鼠的三个受体组之间在肿瘤大小或重量上没有统计学上的显著差异。然而，接受H-2不相合异基因血液的具有免疫活性的小鼠肿瘤植入率更高——盐溶液受体组与异基因受体组相比：卡方值=13.2，自由度=1，p<0.001；同基因受体组与异基因受体组相比：卡方值=2.97，自由度=1，p>0.05。在异基因组中，肿瘤比接受同基因血液或盐溶液的小鼠长得更大、更重。该研究表明，H-2不相合的异基因输血可通过一种涉及细胞介导免疫反应的机制影响可移植小鼠肿瘤的生长。
