Zhou Saijun, Dong Rongna, Wang Junmei, Zhang Li, Yu Bai, Shao Xian, Bai Pufei, Zhang Rui, Ma Yongjian, Yu Pei
NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China.
Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin 300134, China.
J Pers Med. 2022 Oct 19;12(10):1738. doi: 10.3390/jpm12101738.
Variations in the red blood cell (RBC) lifespan can affect glycosylated hemoglobin (HbA1c) test values, but there is still a lack of evidence regarding how and to what degree the RBC lifespan influences HbA1c in the type 2 diabetes mellitus (T2DM) population owing to the restriction of traditional RBC lifespan detection means. In this study, we monitored 464 T2DM patients and 231 healthy control finger blood glucose levels at seven time points for three consecutive months. The HbA1c levels were assessed at the end of the third month as well as the RBC lifespan was measured through the CO breath test. T2DM patients were stratified into four quartile groups according to their RBC lifespans. There was no statistical significance in HbA1c among these four groups. However, the average blood glucose in the Q1 group was significantly higher than those in the other groups. Additionally, the contribution of RBC lifespan to HbA1c test value in the Q1 group was 14.07%, which was significantly higher than those in the other groups. Finally, we used multiple linear regression models to construct a mathematical formula to correct the HbA1c test value in the Q1 group, which would benefit the management of T2DM.
红细胞（RBC）寿命的变化会影响糖化血红蛋白（HbA1c）检测值，但由于传统红细胞寿命检测方法的限制，关于红细胞寿命如何以及在何种程度上影响2型糖尿病（T2DM）人群的HbA1c，仍然缺乏证据。在本研究中，我们连续三个月在七个时间点监测了464例T2DM患者和231例健康对照者的指尖血糖水平。在第三个月末评估HbA1c水平，并通过一氧化碳呼气试验测量红细胞寿命。T2DM患者根据其红细胞寿命被分为四个四分位数组。这四组之间的HbA1c没有统计学意义。然而，Q1组的平均血糖显著高于其他组。此外，Q1组中红细胞寿命对HbA1c检测值的贡献为14.07%，显著高于其他组。最后，我们使用多元线性回归模型构建了一个数学公式来校正Q1组的HbA1c检测值，这将有助于T2DM的管理。
