Ji Dan, Peng Yu, Zhang Yakun, Tang Xinyi, Zhao Mingyu, Ran Longrong, Wu Xuelian, Luo Xin, Chen Shuang, Jiang Tingting, Li Jun, Yang Zailin, Liu Yao
School of Medicine, Chongqing University, Chongqing, 400030, China.
Department of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China.
Heliyon. 2024 Aug 22;10(17):e36507. doi: 10.1016/j.heliyon.2024.e36507. eCollection 2024 Sep 15.
The red blood cell (RBC) lifespan is a crucial indicator used in clinical diagnostics, treatment, and disease monitoring. This biomarker quantifies the duration that red blood cells (RBCs) circulate within the bloodstream after being released from the bone marrow, serving as a sensitive and direct indicator of red blood cell turnover. Conventional techniques for RBC lifespan measurement, including differential agglutination, Cr labeling, and N glycine labeling, each present their own set of challenges, such as complexity, radioactive exposure, and potential allergic reaction. The carbon monoxide (CO) breath test has emerged as an advanced and non-invasive alternative, indirectly assessing RBC lifespan through hemoglobin (Hb) renewal rates. This method is convenient, rapid, and lacks the drawbacks of traditional approaches. The CO breath test for RBC lifespan is widely utilized in benign anemia, malignant hematological disorders, neonatal hyperbilirubinemia, and diabetes mellitus, offering valuable insights into disease mechanisms, progression, and treatment outcomes.
红细胞（RBC）寿命是临床诊断、治疗和疾病监测中使用的关键指标。该生物标志物量化了红细胞从骨髓释放后在血液循环中的持续时间，是红细胞更新的敏感且直接的指标。用于测量RBC寿命的传统技术，包括鉴别凝集、铬标记和N-甘氨酸标记，都存在各自的挑战，如操作复杂、放射性暴露和潜在的过敏反应。一氧化碳（CO）呼气试验已成为一种先进的非侵入性替代方法，通过血红蛋白（Hb）更新率间接评估RBC寿命。该方法方便、快速，且没有传统方法的缺点。用于RBC寿命的CO呼气试验广泛应用于良性贫血、恶性血液系统疾病、新生儿高胆红素血症和糖尿病，为疾病机制、进展和治疗结果提供了有价值的见解。
