Fakhfakh Raouia, Bouallegui Emna, Houssaini Hana, Elloumi Nesrine, Dhafouli Fatma, Abida Olfa, Hachicha Hend, Marzouk Sameh, Bahloul Zouhir, Kammoun Khawla, Boudawara Tahia, Masmoudi Hatem
Autoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, Sfax 3000, Tunisia.
Department of Immunology, Habib Bourguiba University Hospital, University of Sfax, Sfax 3000, Tunisia.
Life (Basel). 2022 Sep 23;12(10):1474. doi: 10.3390/life12101474.
Lupus nephritis (LN) is a type of immunological complex glomerulonephritis characterized by chronic renal inflammation which is exacerbated by infiltrating leukocytes and fueled by a variety of pro-inflammatory cytokines. A profound understanding of the pathogenesis of LN is necessary to identify the optimal molecular targets. The role of RNA-binding proteins (RBPs) in post-transcriptional gene regulation in the immune system is being explored in greater depth to better understand how this regulation is implicated in inflammatory and autoimmune diseases. Tristetraprolin (TTP), Roquin-1/2, and Regnase-1 are 3 RBPs that play a critical role in the regulation of pro-inflammatory mediators by gating the degradation and/or translational silencing of target mRNAs. In this study, we proposed to focus on the differential expression of these RBPs in immune cells and renal biopsies from LN patients, as well as their regulatory impact on a specific target. Herein, we highlight a novel target of anti-inflammatory treatment by revealing the mechanisms underlying RBP expression and the interaction between RBPs and their target RNAs.
狼疮性肾炎（LN）是一种免疫复合物性肾小球肾炎，其特征为慢性肾脏炎症，这种炎症会因浸润的白细胞而加剧，并由多种促炎细胞因子驱动。深入了解LN的发病机制对于确定最佳分子靶点至关重要。人们正在更深入地探索RNA结合蛋白（RBP）在免疫系统转录后基因调控中的作用，以便更好地理解这种调控如何与炎症和自身免疫性疾病相关。锌指蛋白36（TTP）、锌指蛋白A20（Roquin-1/2）和核糖核酸酶E1（Regnase-1）是三种RBP，它们通过控制靶mRNA的降解和/或翻译沉默，在促炎介质的调控中发挥关键作用。在本研究中，我们提议重点关注这些RBP在LN患者免疫细胞和肾活检组织中的差异表达，以及它们对特定靶点的调控作用。在此，我们通过揭示RBP表达的潜在机制以及RBP与其靶RNA之间的相互作用，突出了抗炎治疗的一个新靶点。
