Department of Anaesthesiology & Perioperative Medicine, Mater Misericordiae University Hospital, D07 R2WY Dublin, Ireland.
Department of Anaesthesiology, Mater Private Hospital, Eccles Street, D07 WKW8 Dublin, Ireland.
Medicina (Kaunas). 2022 Oct 1;58(10):1380. doi: 10.3390/medicina58101380.
The incidence and societal burden of cancer is increasing globally. Surgery is indicated in the majority of solid tumours, and recent research in the emerging field of onco-anaesthesiology suggests that anaesthetic-analgesic interventions in the perioperative period could potentially influence long-term oncologic outcomes. While prospective, randomised controlled clinical trials are the only research method that can conclusively prove a causal relationship between anaesthetic technique and cancer recurrence, live animal (in vivo) experimental models may more realistically test the biological plausibility of these hypotheses and the mechanisms underpinning them, than limited in vitro modelling. This review outlines the advantages and limitations of available animal models of cancer and how they might be used in perioperative cancer metastasis modelling, including spontaneous or induced tumours, allograft, xenograft, and transgenic tumour models.
癌症的发病率和社会负担在全球范围内不断增加。手术适用于大多数实体肿瘤，而肿瘤麻醉学这一新兴领域的最新研究表明，围手术期的麻醉-镇痛干预可能会对长期肿瘤学结果产生影响。虽然前瞻性、随机对照临床试验是唯一能够确定麻醉技术与癌症复发之间因果关系的研究方法，但活体（体内）实验模型可能比有限的体外模型更能真实地检验这些假说的生物学合理性及其背后的机制。本文综述了现有的癌症动物模型的优缺点，以及它们如何在围手术期癌症转移模型中得到应用，包括自发性或诱导性肿瘤、同种异体移植、异种移植和转基因肿瘤模型。
