Lee T K, Chen Y C, Kuo T L
Thromb Res. 1987 Aug 1;47(3):295-304. doi: 10.1016/0049-3848(87)90143-5.
The aim of this study was to observe whether acetylsalicylic acid (ASA) had different effects in both sexes. Out of the ischemic stroke patients who were admitted to the National Taiwan University Hospital (NTUH), those who had not taken ASA or ASA-like drugs for more than 2 weeks were selected for this study. For the diagnosis of ischemic stroke, computed tomography (CT) of the brain was performed in all cases, and for differential diagnosis, other necessary procedures were employed in a few cases. The serum salicylate (SA) level was measured by Trinder's method, thromboxane B2 (TXB2) and 6-keto-PGF1 alpha by radioimmunoassay, threshold concentration of adenosine diphosphate (ADP) by Born's method, and circulating platelet aggregates (CPA) by Wu and Hoak's method. The present study showed that the means of serum SA levels after administration of the same dose of ASA were not significantly different between the two sexes. After ingestion of ASA, a single dose of 75 mg, 300 mg or 600 mg, or 300 mg 4 times a day, mean plasma TXB2 levels were significantly suppressed and mean threshold concentrations of ADP were significantly elevated in the two sexes. After administration of above-mentioned various doses of ASA, the abnormally high plasma TXB2 levels and abnormally low threshold concentrations of ADP and CPA ratios were significantly normalized in both male and female patients. Plasma 6-keto-PGF1 alpha levels were not influenced by ingestion of ASA 75 mg, but significantly depressed by administration of ASA 300 mg in both sexes. There were no sex differences in the antiplatelet effect of ASA in this experiment.
本研究的目的是观察阿司匹林（ASA）在两性中是否具有不同的作用。在国立台湾大学医院（NTUH）收治的缺血性中风患者中，选择那些未服用ASA或类ASA药物超过2周的患者进行本研究。对于缺血性中风的诊断，所有病例均进行了脑部计算机断层扫描（CT），少数病例采用了其他必要的鉴别诊断程序。血清水杨酸（SA）水平采用Trinder法测定，血栓素B2（TXB2）和6-酮-前列腺素F1α采用放射免疫分析法测定，二磷酸腺苷（ADP）的阈值浓度采用Born法测定，循环血小板聚集物（CPA）采用Wu和Hoak法测定。本研究表明，给予相同剂量的ASA后，两性血清SA水平的均值无显著差异。摄入ASA后，单剂量75mg、300mg或600mg，或每天4次300mg，两性的平均血浆TXB2水平均显著降低，ADP的平均阈值浓度均显著升高。给予上述不同剂量的ASA后，男性和女性患者血浆TXB2水平异常升高、ADP阈值浓度异常降低以及CPA比值异常均显著恢复正常。血浆6-酮-前列腺素F1α水平不受75mg ASA摄入的影响，但两性给予300mg ASA后均显著降低。本实验中ASA的抗血小板作用无性别差异。
