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糖尿病作为接受肾移植治疗的患者尿路感染的预测因素。

Diabetes Mellitus as a Predictive Factor for Urinary Tract Infection for Patients Treated with Kidney Transplantation.

机构信息

Department of Urology, Ogaki Municipal Hospital, Ogaki 5038502, Japan.

Department of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan.

出版信息

Medicina (Kaunas). 2022 Oct 19;58(10):1488. doi: 10.3390/medicina58101488.

Abstract

: We aimed to investigate the rate of incidence and risk factors of post-transplant urinary tract infection (UTI) in patients receiving kidney transplantation (KT) at our institution. : A retrospective cohort study was carried out on patients who underwent KT for end-stage kidney disease (ESKD) from January 2008 to December 2021 at Gifu University Hospital. UTI was defined as the existence of bacterial and/or fungal infection in urine with ≥105 colony-forming units/mL, with or without urinary and/or systemic symptoms of UTI. Patients were divided into two groups: those with UTI after KT (UTI group) and those without UTI (non-UTI group). The primary endpoint of this study was the relationship between covariates and UTI after KT. : Two hundred and forty patients with ESKD received KT at Gifu University Hospital. Thirty-four participants developed UTI after surgery, and the most common pathogen was . At the end of the follow-up, graft loss was observed in six patients (2.5%), independent of UTI episodes. In the multivariate analysis, diabetes mellitus (DM) was statistically associated with post-transplant UTI in kidney transplant recipients. : Preoperative serum glucose control in patients with DM may have a crucial role in preventing UTI and preserving renal function after KT.

摘要

我们旨在调查本机构肾移植(KT)患者术后尿路感染(UTI)的发生率和风险因素。

对 2008 年 1 月至 2021 年 12 月在岐阜大学医院接受终末期肾病(ESKD)KT 的患者进行了回顾性队列研究。UTI 的定义为尿液中存在细菌和/或真菌感染,≥105 个菌落形成单位/毫升,伴有或不伴有 UTI 的尿路和/或全身症状。患者分为两组:KT 后发生 UTI(UTI 组)和未发生 UTI(非 UTI 组)。本研究的主要终点是协变量与 KT 后 UTI 的关系。

240 名 ESKD 患者在岐阜大学医院接受 KT。34 名参与者术后发生 UTI,最常见的病原体是 。在随访结束时,6 名患者(2.5%)发生移植物丢失,与 UTI 发作无关。多变量分析显示,糖尿病(DM)与肾移植受者术后 UTI 有统计学关联。

DM 患者术前血清血糖控制可能对预防 UTI 和保护 KT 后肾功能至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3cb/9610755/3bd488abc9bf/medicina-58-01488-g001.jpg

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