Gondos Adnan S, Al-Moyed Khaled A, Al-Robasi Abdul Baki A, Al-Shamahy Hassan A, Alyousefi Naelah A
Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
PLoS One. 2015 Dec 10;10(12):e0144266. doi: 10.1371/journal.pone.0144266. eCollection 2015.
Urinary tract infection (UTI) is the most common complication following kidney transplantation (KT), which could result in losing the graft. This study aims to identify the prevalence of bacterial UTI among KT recipients in Yemen and to determine the predisposing factors associated with post renal transplantation UTI. A cross sectional study included of 150 patients, who underwent KT was conducted between June 2010 and January 2011. A Morning mid-stream urine specimen was collected for culture and antibiotic susceptibility test from each recipient. Bacterial UTI was found in 50 patients (33.3%). The prevalence among females 40.3% was higher than males 29%. The UTI was higher in the age group between 41-50 years with a percentage of 28% and this result was statistically significant. Predisposing factors as diabetes mellitus, vesicoureteral reflux, neurogenic bladder and polycystic kidney showed significant association. High relative risks were found for polycystic kidney = 13.5 and neurogenic bladder = 13.5. The most prevalent bacteria to cause UTI was Escherichia coli represent 44%, followed by Staphylococcus saprophyticus 34%. Amikacin was the most effective antibiotic against gram-negative isolates while Ciprofloxacin was the most effective antibiotic against Staphylococcus saprophyticus. In conclusion, there is high prevalence of bacterial UTI among KT recipients in Yemen. Diabetes mellitus, vesicoureteral reflux, neurogenic bladder, polycystic kidney and calculi were the main predisposing factors.
尿路感染（UTI）是肾移植（KT）后最常见的并发症，可能导致移植肾丧失。本研究旨在确定也门肾移植受者中细菌性UTI的患病率，并确定与肾移植后UTI相关的易感因素。2010年6月至2011年1月期间，对150例接受KT的患者进行了一项横断面研究。从每位受者收集晨起中段尿标本进行培养和药敏试验。50例患者（33.3%）发现细菌性UTI。女性患病率为40.3%，高于男性的29%。41-50岁年龄组的UTI患病率较高，为28%，这一结果具有统计学意义。糖尿病、膀胱输尿管反流、神经源性膀胱和多囊肾等易感因素显示出显著相关性。多囊肾的相对风险较高=13.5，神经源性膀胱=13.5。引起UTI最常见的细菌是大肠杆菌，占44%，其次是腐生葡萄球菌，占34%。阿米卡星是对抗革兰氏阴性菌分离株最有效的抗生素，而环丙沙星是对抗腐生葡萄球菌最有效的抗生素。总之，也门肾移植受者中细菌性UTI的患病率较高。糖尿病、膀胱输尿管反流、神经源性膀胱、多囊肾和结石是主要的易感因素。
