Nash T E, Ottesen E A, Cheever A W
Am J Trop Med Hyg. 1978 Sep;27(5):944-50. doi: 10.4269/ajtmh.1978.27.944.
Specific IgM and IgG antibody to a polysaccharide present in the epithelial cells of the gut of adult schistosomes was measured in four groups of infected patients: I) patients with documented acute schistosomiasis; II) Americans exposed to schistosomiasis within the preceding 0--4 years; III) chronically and heavily infected patients, mostly from Puerto Rico, without hepatomegaly or hepatosplenomegaly; and IV) heavily infected Brazilian children with hepatic or hepatosplenic schistosomiasis. Specific IgM and IgG titers were both highest in the acute Group I patients and lowest in the chronically infected Groups III and IV. Total IgG and IgM levels were compared to specific antibody titers. Immunoglobulin levels tended to follow specific antibody titers except in the chronically infected Groups III and IV in which total IgG rose to high levels. The decrease in specific antigen titers over the course of time occurred despite continued antigenic stimulation and suggests a modulation of the humoral response. The mechanism remains obscure.
在四组感染患者中检测了针对成年血吸虫肠道上皮细胞中一种多糖的特异性IgM和IgG抗体：I）确诊为急性血吸虫病的患者；II）在过去0至4年内接触过血吸虫病的美国人；III）慢性重度感染患者，大多来自波多黎各，无肝肿大或肝脾肿大；IV）患有肝或肝脾血吸虫病的重度感染巴西儿童。特异性IgM和IgG滴度在急性I组患者中最高，在慢性感染的III组和IV组中最低。将总IgG和IgM水平与特异性抗体滴度进行了比较。免疫球蛋白水平往往与特异性抗体滴度一致，但在慢性感染的III组和IV组中，总IgG升至高水平。尽管持续存在抗原刺激，但随着时间推移特异性抗原滴度仍下降，这表明体液反应受到了调节。其机制仍不清楚。
