Lee Chiang-Wen, Liu Ju-Fang, Wei Wen-Chun, Chiang Ming-Hsien, Chen Ting-Yuan, Liao Shu-Hsien, Chiang Yao-Chang, Kuo Wen-Cheng, Chen Kuen-Lin, Peng Kuo-Ti, Liu Yen-Bin, Chieh Jen-Jie
Department of Nursing, Division of Basic Medical Sciences, Chronic Diseases and Health Promotion Research Center and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Puzi City 61363, Taiwan.
Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi City 61363, Taiwan.
Micromachines (Basel). 2022 Sep 27;13(10):1605. doi: 10.3390/mi13101605.
Ablation is a clinical cancer treatment, but some demands are still unsatisfied, such as electromagnetic interferences amongst multiple ablation needles during large tumour treatments. This work proposes a physical synthesis for composite particles of biocompatible iron oxide particles and liquid metal gallium (Ga) with different alternative-current (AC)-magnetic-field-induced heat mechanisms of magnetic particle hyperthermia and superior resistance heat. By some imaging, X-ray diffraction, and vibrating sample magnetometer, utilised composite particles were clearly identified as the cluster of few iron oxides using the small weight ratio of high-viscosity liquid metal Ga as conjugation materials without surfactants for physical targeting of limited fluidity. Hence, well penetration inside the tissue and the promotion rate of heat generation to fit the ablation requirement of at least 60 °C in a few seconds are achieved. For the injection and the post-injection magnetic ablations, the volume variation ratios of mice dorsal tumours on Day 12 were expressed at around one without tumour growth. Its future powerful potentiality is expected through a percutaneous injection.
消融是一种临床癌症治疗方法,但仍有一些需求未得到满足,例如在大型肿瘤治疗过程中多个消融针之间的电磁干扰。这项工作提出了一种生物相容性氧化铁颗粒与液态金属镓(Ga)复合颗粒的物理合成方法,该复合颗粒具有磁颗粒热疗和优异电阻热的不同交流(AC)磁场诱导热机制。通过一些成像、X射线衍射和振动样品磁强计,利用高粘度液态金属Ga作为共轭材料,以小重量比且无表面活性剂用于有限流动性的物理靶向,所使用的复合颗粒被明确鉴定为少量氧化铁的簇。因此,实现了在组织内的良好渗透以及在几秒钟内将发热促进率提高到符合至少60°C的消融要求。对于注射和注射后磁消融,第12天小鼠背部肿瘤的体积变化率在无肿瘤生长的情况下约为1。通过经皮注射预计其未来具有强大的潜力。
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Int J Hyperthermia. 1997
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Nanoscale Adv. 2019-6-1
Theranostics. 2019-5-31
Colloids Surf B Biointerfaces. 2018-4-27