文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

用于肿瘤磁消融的合成导电/磁性复合粒子

Synthesised Conductive/Magnetic Composite Particles for Magnetic Ablations of Tumours.

作者信息

Lee Chiang-Wen, Liu Ju-Fang, Wei Wen-Chun, Chiang Ming-Hsien, Chen Ting-Yuan, Liao Shu-Hsien, Chiang Yao-Chang, Kuo Wen-Cheng, Chen Kuen-Lin, Peng Kuo-Ti, Liu Yen-Bin, Chieh Jen-Jie

机构信息

Department of Nursing, Division of Basic Medical Sciences, Chronic Diseases and Health Promotion Research Center and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Puzi City 61363, Taiwan.

Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi City 61363, Taiwan.

出版信息

Micromachines (Basel). 2022 Sep 27;13(10):1605. doi: 10.3390/mi13101605.


DOI:10.3390/mi13101605
PMID:36295958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9611394/
Abstract

Ablation is a clinical cancer treatment, but some demands are still unsatisfied, such as electromagnetic interferences amongst multiple ablation needles during large tumour treatments. This work proposes a physical synthesis for composite particles of biocompatible iron oxide particles and liquid metal gallium (Ga) with different alternative-current (AC)-magnetic-field-induced heat mechanisms of magnetic particle hyperthermia and superior resistance heat. By some imaging, X-ray diffraction, and vibrating sample magnetometer, utilised composite particles were clearly identified as the cluster of few iron oxides using the small weight ratio of high-viscosity liquid metal Ga as conjugation materials without surfactants for physical targeting of limited fluidity. Hence, well penetration inside the tissue and the promotion rate of heat generation to fit the ablation requirement of at least 60 °C in a few seconds are achieved. For the injection and the post-injection magnetic ablations, the volume variation ratios of mice dorsal tumours on Day 12 were expressed at around one without tumour growth. Its future powerful potentiality is expected through a percutaneous injection.

摘要

消融是一种临床癌症治疗方法,但仍有一些需求未得到满足,例如在大型肿瘤治疗过程中多个消融针之间的电磁干扰。这项工作提出了一种生物相容性氧化铁颗粒与液态金属镓(Ga)复合颗粒的物理合成方法,该复合颗粒具有磁颗粒热疗和优异电阻热的不同交流(AC)磁场诱导热机制。通过一些成像、X射线衍射和振动样品磁强计,利用高粘度液态金属Ga作为共轭材料,以小重量比且无表面活性剂用于有限流动性的物理靶向,所使用的复合颗粒被明确鉴定为少量氧化铁的簇。因此,实现了在组织内的良好渗透以及在几秒钟内将发热促进率提高到符合至少60°C的消融要求。对于注射和注射后磁消融,第12天小鼠背部肿瘤的体积变化率在无肿瘤生长的情况下约为1。通过经皮注射预计其未来具有强大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/4589d45e0d89/micromachines-13-01605-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/d51d86078fa2/micromachines-13-01605-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/dba0dd9e0759/micromachines-13-01605-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/a25889513c8f/micromachines-13-01605-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/4589d45e0d89/micromachines-13-01605-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/d51d86078fa2/micromachines-13-01605-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/dba0dd9e0759/micromachines-13-01605-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/a25889513c8f/micromachines-13-01605-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c537/9611394/4589d45e0d89/micromachines-13-01605-g004.jpg

相似文献

[1]
Synthesised Conductive/Magnetic Composite Particles for Magnetic Ablations of Tumours.

Micromachines (Basel). 2022-9-27

[2]
Highly efficient magnetic ablation and the contrast of various imaging using biocompatible liquid-metal gallium.

Biomed Eng Online. 2022-6-17

[3]
Real-time infrared thermography detection of magnetic nanoparticle hyperthermia in a murine model under a non-uniform field configuration.

Int J Hyperthermia. 2013-10-18

[4]
Preparation and characterization of hydroxyapatite-coated iron oxide particles by spray-drying technique.

An Acad Bras Cienc. 2009-6

[5]
Formation of inorganic liquid gallium particle-manganese oxide composites.

Nanoscale. 2023-3-2

[6]
Hyperthermia treatment of cancer cells by the application of targeted silk/iron oxide composite spheres.

Mater Sci Eng C Mater Biol Appl. 2021-1

[7]
Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo.

Int J Hyperthermia. 1997

[8]
Synthesis and heating effect of iron/iron oxide composite and iron oxide nanoparticles.

Proc SPIE Int Soc Opt Eng. 2007-2-9

[9]
Sub-micrometer particles produced by a low-powered AC electric arc in liquids.

J Nanosci Nanotechnol. 2012-1

[10]
The effect of tumour size on ferromagnetic embolization hyperthermia in a rabbit liver tumour model.

Int J Hyperthermia. 2002

本文引用的文献

[1]
Correction: Highly efficient magnetic ablation and the contrast of various imaging using biocompatible liquid-metal gallium.

Biomed Eng Online. 2022-7-20

[2]
Development, Therapeutic Evaluation and Theranostic Applications of Cubosomes on Cancers: An Updated Review.

Pharmaceutics. 2022-3-9

[3]
Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles.

Adv Sci (Weinh). 2021-1-18

[4]
Gallium-Based Liquid Metal Particles for Therapeutics.

Trends Biotechnol. 2021-6

[5]
Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications.

Theranostics. 2020

[6]
Antibacterial Liquid Metals: Biofilm Treatment Magnetic Activation.

ACS Nano. 2020-1-10

[7]
Indirect magnetic force microscopy.

Nanoscale Adv. 2019-6-1

[8]
PMMA-FeO for internal mechanical support and magnetic thermal ablation of bone tumors.

Theranostics. 2019-5-31

[9]
Clavanin A-bioconjugated FeO/Silane core-shell nanoparticles for thermal ablation of bacterial biofilms.

Colloids Surf B Biointerfaces. 2018-4-27

[10]
Eight-Channel AC Magnetosusceptometer of Magnetic Nanoparticles for High-Throughput and Ultra-High-Sensitivity Immunoassay.

Sensors (Basel). 2018-3-30

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索