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Embryotoxic evaluation of a Prudhoe Bay crude oil in rats.

作者信息

Khan S, Martin M, Payne J F, Rahimtula A D

出版信息

Toxicol Lett. 1987 Sep;38(1-2):109-14. doi: 10.1016/0378-4274(87)90118-4.

DOI:10.1016/0378-4274(87)90118-4
PMID:3629623
Abstract

The embryotoxic potential of a Prudhoe Bay crude oil (PBCO) was investigated in rats. PBCO was administered orally to pregnant rats as (i) a single dose on various gestation days, (ii) a single variable dose on gestation day 6, or (iii) as daily doses from day 6 to day 17 of pregnancy. PBCO administered during the earlier stages of pregnancy (day 3, 6 or 11) but not during the later stages, affected the reproductive performance of pregnant rats by significantly increasing the number of resorptions including fetal death and by decreasing the fetal weight. A dose-dependent increase in fetomortality was also observed. Multiple exposure to low levels of crude oil also caused a significant reduction in maternal body weight besides other embryotoxic changes.

摘要

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