Santo Évellin do Espirito, Ishii Marina, Pinto Uelinton Manoel, Matsudo Marcelo Chuei, Carvalho João Carlos Monteiro de
Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508900, Brazil.
Research Center, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508900, Brazil.
Microorganisms. 2022 Oct 14;10(10):2029. doi: 10.3390/microorganisms10102029.
The applications of microalgae biomass have been widely studied worldwide. The classical processes used in outdoor cultivations of microalgae, in closed or open photobioreactors, occur in the presence of bacteria. Understanding how communication between cells occurs through quorum sensing and evaluating co-cultures allows the production of microalgae and cyanobacteria to be positively impacted by bacteria, in order to guarantee safety and profitability in the production process. In addition, the definition of the effects that occur during an interaction, promotes insights to improve the production of biomolecules, and to develop innovative products. This review presents the interactions between microalgae and bacteria, including compounds exchanges and communication, and addresses the development of new pharmaceutical, cosmetic and food bioproducts from microalgae based on these evaluations, such as prebiotics, vegan skincare products, antimicrobial compounds, and culture media with animal free protein for producing vaccines and other biopharmaceutical products. The use of microalgae as raw biomass or in biotechnological platforms is in line with the fulfillment of the 2030 Agenda related to the Sustainable Development Goals (SDGs).
微藻生物质的应用在全球范围内得到了广泛研究。微藻在封闭或开放式光生物反应器中的户外培养所采用的传统工艺是在有细菌存在的情况下进行的。了解细胞间如何通过群体感应进行通讯并评估共培养情况，有助于微藻和蓝细菌的生产受到细菌的积极影响，从而确保生产过程的安全性和盈利性。此外，明确相互作用过程中产生的影响，有助于深入了解如何提高生物分子的产量以及开发创新产品。本综述介绍了微藻与细菌之间的相互作用，包括化合物交换和通讯，并基于这些评估探讨了基于微藻的新型医药、化妆品和食品生物产品的开发，如益生元、纯素护肤品、抗菌化合物以及用于生产疫苗和其他生物制药产品的无动物蛋白培养基。将微藻用作原始生物质或用于生物技术平台符合与可持续发展目标（SDGs）相关的《2030年议程》的要求。
