Labara Tirado Joan, Herdean Andrei, Ralph Peter J
Faculty of Science, Climate Change Cluster (C3), Algal Biotechnology & Biosystems, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Nat Prod Bioprospect. 2025 Jan 16;15(1):7. doi: 10.1007/s13659-024-00487-3.
Microalgae's adaptability and resilience to Earth's diverse environments have evolved these photosynthetic microorganisms into a biotechnological source of industrially relevant physiological functions and biometabolites. Despite this, microalgae-based industries only exploit a handful of species. This lack of biodiversity hinders the expansion of the microalgal industry. Microalgal bioprospecting, searching for novel biological algal resources with new properties, remains a low throughput and time-consuming endeavour due to inefficient workflows that rely on non-selective sampling, monoalgal culture status and outdated, non-standardized characterization techniques. This review will highlight the importance of microalgal bioprospecting and critically explore commonly employed methodologies. We will also explore current advances driving the next generation of smart algal bioprospecting focusing on novel workflows and transdisciplinary methodologies with the potential to enable high-throughput microalgal biodiscoveries. Images adapted from (Addicted04 in Wikipedia File: Australia on the globe (Australia centered).svg. 2014.; Jin et al. in ACS Appl Bio Mater 4:5080-5089, 2021; Kim et al. in Microchim Acta 189:88, 2022; Tony et al. in Lab on a Chip 15, 19:3810-3810; Thermo Fisher Scientific INC. in CTS Rotea Brochure).
微藻对地球多样环境的适应性和恢复力，已使这些光合微生物演变成具有工业相关生理功能和生物代谢物的生物技术来源。尽管如此，基于微藻的产业仅利用了少数几个物种。这种生物多样性的缺乏阻碍了微藻产业的扩张。微藻生物勘探，即寻找具有新特性的新型生物藻类资源，由于依赖非选择性采样、单藻培养状态以及过时的、非标准化的表征技术的低效工作流程，仍然是一项低通量且耗时的工作。本综述将强调微藻生物勘探的重要性，并批判性地探讨常用方法。我们还将探索推动下一代智能藻类生物勘探的当前进展，重点关注具有实现高通量微藻生物发现潜力的新型工作流程和跨学科方法。图片改编自（维基百科文件：澳大利亚在全球的位置（澳大利亚居中）.svg中的Addicted04。2014年；ACS应用生物材料4:5080 - 5089中的Jin等人，2021年；微化学学报189:88中的Kim等人，2022年；芯片实验室15, 19:3810 - 3810中的Tony等人；赛默飞世尔科技公司的CTS Rotea手册）
