使用改良的斯蒂尔-根纳里型试剂进行高选择性霍纳-沃思瓦尔德-埃蒙斯（Horner-Wadsworth-Emmons）烯烃化反应。
Highly -Selective Horner-Wadsworth-Emmons Olefination Using Modified Still-Gennari-Type Reagents.
机构信息
Division of Organic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland.
出版信息
Molecules. 2022 Oct 21;27(20):7138. doi: 10.3390/molecules27207138.
Abstract
In this report, new, easily accessible reagents for highly -selective HWE reactions are presented. Alkyl di-(1,1,1,3,3,3-hexafluoroisopropyl)phosphonoacetates, structurally similar to Still-Gennari type reagents, were tested in HWE reactions with a series of various aldehydes. Very good -selectivity (up to a 98:2 : ratio) was achieved in most cases along with high yields. Application of the new reagents may be a valuable, practical alternative to the well-established Still-Gennari or Ando -selective carbonyl group olefination protocols.
摘要
在本报告中，我们提出了一些新的、易于获得的试剂，用于高度选择性的 HWE 反应。结构上类似于斯蒂尔-根纳里型试剂的烷基二-(1,1,1,3,3,3-六氟异丙基)膦酸酯，在与一系列不同醛的 HWE 反应中进行了测试。在大多数情况下，都实现了非常好的选择性（高达 98:2 的比例）和高收率。这些新型试剂的应用可能是对成熟的斯蒂尔-根纳里或安多选择性羰基烯烃化方案的一种有价值的、实用的替代方法。
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