利用去对称化方案全合成（-）-替兰霉素 C。
Total synthesis of (-)-tirandamycin C utilizing a desymmetrization protocol.
机构信息
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
出版信息
J Org Chem. 2012 Nov 2;77(21):9628-33. doi: 10.1021/jo3016709. Epub 2012 Oct 17.
PMID:23039073
Abstract
A highly stereoselective total synthesis of (-)-tirandamycin C has been achieved following a desymmetrization protocol developed in our group, Horner-Wadsworth-Emmons olefination, acid-catalyzed ketalization, Still-Gennari (Z)-selective olefination, and Dieckmann cyclization as key reactions.
摘要
我们组开发了一种不对称拆分方案，通过该方案实现了（-）-替兰霉素 C 的高度对映选择性全合成，其中关键反应包括：霍纳-沃兹沃思-埃蒙斯（Horner-Wadsworth-Emmons）烯烃化、酸催化缩酮化、斯蒂尔-根纳里（Still-Gennari）（Z）选择性烯烃化和迪克曼（Dieckmann）环化。
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