Johora Fatema Tuj, Kibria Mohammad Golam, Fuehrer Hans-Peter, Alam Mohammad Shafiul
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Pathogens. 2022 Sep 21;11(10):1072. doi: 10.3390/pathogens11101072.
is a neglected human malaria parasite with low parasitemia that often results in the misdiagnosis and underestimation of the actual disease burden of this pathogen. Microscopy is the best diagnostic tool, despite the fact that rapid diagnostic tests (RDTs) are the best surveillance tool for malaria diagnosis in many rural areas for their ease of use in elimination settings. For parasite antigen detection other than , RDTs depend on essential glycolytic proteins, i.e., lactate dehydrogenase (pLDH) and aldolase (pAldo) antigens. There is a lack of species-specific test kits for , and overall, its rapid antigenic test accuracy is questionable. False negative results can accelerate the burden of asymptomatic malaria infection and transmission. Here, we report a case of a malaria patient in Bangladesh infected with who tested negative on pLDH and pAldo based RDTs. This case provides useful information for health providers to be aware of possible RDT failure and also for the future development of analytically sensitive test kits for
是一种被忽视的人类疟原虫，其寄生虫血症水平较低，这常常导致对该病原体实际疾病负担的误诊和低估。显微镜检查是最佳诊断工具，尽管快速诊断检测（RDTs）因其在疟疾消除环境中易于使用，是许多农村地区疟疾诊断的最佳监测工具。对于除[具体寄生虫名称]之外的寄生虫抗原检测，RDTs依赖于关键的糖酵解蛋白，即疟原虫乳酸脱氢酶（pLDH）和醛缩酶（pAldo）抗原。缺乏针对[具体寄生虫名称]的物种特异性检测试剂盒，总体而言，其快速抗原检测的准确性存疑。假阴性结果会加重无症状疟疾感染和传播的负担。在此，我们报告一例孟加拉国的疟疾患者，其感染了[具体寄生虫名称]，基于pLDH和pAldo的RDTs检测呈阴性。该病例为医疗服务提供者了解RDTs可能出现的失败情况提供了有用信息，也为未来开发分析灵敏的检测试剂盒提供了参考。
