Liu Ziqian, Ramakrishna Seeram, Ahmed Ifty, Rudd Chris, Liu Xiaoling
Department of Mechanical, Materials and Manufacturing Engineering, The University of Nottingham Ningbo China, Ningbo 315100, China.
Department of Mechanical Engineering, National University of Singapore, Singapore 119077, Singapore.
Polymers (Basel). 2022 Oct 19;14(20):4411. doi: 10.3390/polym14204411.
In this study, solutions were prepared with fixed concentrations of hyaluronic acid (HA) but varied concentrations of poly (lactic-co-glycolic acid) (PLGA) to emphasize the effects of PLGA concentration and HA addition on solution properties and to further evaluate their electrospinning performance. The dependence of specific viscosity on PLGA concentration was studied to determine the concentration regimes and evaluate the critical concentration (C) for successful fiber generation. The C of PLGA solutions is 12.07% compared to 10.09% for PLGA-HA solutions. Blending with HA results in a lower concentration dependence and better consistency to the theoretical scaling mechanisms due to the additional topological constrains, which thus result in more chain entanglements. Solutions in semi-dilute entangled regimes show the crossover of complex moduli, verifying the stable and reliable entanglement network. Higher concentrations and HA addition both led to lower crossover frequencies and, thus, a longer relaxation time. The effects of a higher PLGA concentration and HA addition on the surface tension were not evident. However, the HA addition significantly improved the solution conductivity up to three times in the pure PLGA solutions due to its polyelectrolyte nature. Defect-free and uniform nanofibers were generated from 35% to 40% of the PLGA-HA solutions, yet fibers with bead-on-string structures were produced from all studied pure PLGA solutions. Such solution characteristics and parametric correlations can provide predictive insights on tailoring the morphological characteristics of nanofibers for specific applications.
在本研究中，制备了固定浓度透明质酸（HA）但聚（乳酸 - 乙醇酸）（PLGA）浓度不同的溶液，以强调PLGA浓度和HA添加对溶液性质的影响，并进一步评估其静电纺丝性能。研究了比浓粘度对PLGA浓度的依赖性，以确定浓度范围并评估成功生成纤维的临界浓度（C）。PLGA溶液的C为12.07%，而PLGA - HA溶液的C为10.09%。与HA混合由于额外的拓扑约束导致浓度依赖性降低，并且与理论标度机制具有更好的一致性，从而导致更多的链缠结。半稀缠结状态下的溶液显示出复数模量的交叉，验证了稳定可靠的缠结网络。较高的浓度和HA添加都导致较低的交叉频率，因此具有更长的弛豫时间。较高的PLGA浓度和HA添加对表面张力的影响不明显。然而，由于HA的聚电解质性质，在纯PLGA溶液中，HA添加显著提高了溶液电导率，最高可达三倍。从35%至40%的PLGA - HA溶液中生成了无缺陷且均匀的纳米纤维，但所有研究的纯PLGA溶液都产生了串珠状结构的纤维。这样的溶液特性和参数相关性可以为针对特定应用定制纳米纤维的形态特征提供预测性见解。
Zotero 插件
