医护人员对BNT162b2 mRNA新冠疫苗加强针的抗体反应：IgG抗体滴度与人体测量和身体成分参数之间的关联

The Antibody Response to the BNT162b2 mRNA COVID-19 Booster in Healthcare Workers: Association between the IgG Antibody Titers and Anthropometric and Body Composition Parameters.

作者信息

Golec Marlena, Konka Adam, Fronczek Martyna, Zembala-John Joanna, Chrapiec Martyna, Wystyrk Karolina, Kasperczyk Sławomir, Brzoza Zenon, Bułdak Rafał Jakub

机构信息

Silesian Park of Medical Technology Kardio-Med Silesia, M. Curie-Skłodowskiej 10C, 41-800 Zabrze, Poland.

Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, H. Jordana 38, 41-808 Zabrze, Poland.

出版信息

Vaccines (Basel). 2022 Sep 29;10(10):1638. doi: 10.3390/vaccines10101638.

DOI:10.3390/vaccines10101638

PMID:36298503

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9611156/

Abstract

BACKGROUND

Research shows that in most people, two-dose vaccination helps to shape the humoral response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Further studies are required to learn about the vaccine's effectiveness after boosting.

METHODS

We conducted a prospective study among 103 healthcare workers (HCWs) from a regional multi-specialty hospital vaccinated with three doses of the BNT162b2 vaccine. We compared their immunoglobulin G (IgG) titers 14 days after the second dose with those 21 days after the booster. We also compared their anthropometric and body composition parameters with IgG concentrations at the same time points.

RESULTS

Twenty-one days after the booster, all study participants were seropositive. Their mean IgG antibody titers were significantly lower than 14 days after the second dose (158.94 AU/mL ± 90.34 AU/mL vs. 505.79 AU/mL ± 367.16 AU/mL). Post-booster Spearman's correlation analysis showed a significantly weak correlation between the IgG antibody titer and parameters related to muscle tissue and adipose tissue (including body fat mass).

CONCLUSIONS

The BNT162b2 booster stimulates the humoral response to a lesser extent than the two-dose BNT162b2 primary vaccination. The adipose and muscle tissue parameters show a weak positive correlation with the SARS-CoV-2 IgG antibody titers.

摘要

背景

研究表明，对大多数人而言，两剂疫苗接种有助于形成对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的体液免疫反应。还需要进一步研究以了解加强接种后疫苗的有效性。

方法

我们对一家地区多专科医院的103名接种三剂BNT162b2疫苗的医护人员（HCW）进行了一项前瞻性研究。我们比较了他们在第二剂接种后14天和加强接种后21天的免疫球蛋白G（IgG）滴度。我们还在相同时间点比较了他们的人体测量和身体成分参数与IgG浓度。

结果

加强接种后21天，所有研究参与者血清学均呈阳性。他们的平均IgG抗体滴度显著低于第二剂接种后14天（158.94 AU/mL±90.34 AU/mL对505.79 AU/mL±367.16 AU/mL）。加强接种后进行的Spearman相关性分析显示，IgG抗体滴度与肌肉组织和脂肪组织相关参数（包括体脂量）之间存在显著弱相关性。