Silesian Park of Medical Technology Kardio-Med Silesia, M. Curie-Skłodowskiej 10C, 41-800 Zabrze, Poland.
Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, H. Jordana 38, 41-808 Zabrze, Poland.
Viruses. 2022 Apr 22;14(5):868. doi: 10.3390/v14050868.
This study aimed to investigate the early and longitudinal humoral response in Healthcare Workers (HCWs) after two doses of the BNT162b2 vaccine and to assess the association between metabolic and anthropometric parameters and the humoral response after vaccination.
The study included 243 fully vaccinated HCWs: 25.50% previously infected with SARS-CoV-2 (with prior history of COVID-19-PH) and 74.40%-uninfected, seronegative before the first vaccination (with no prior history of COVID-19-NPH). IgG antibodies were measured, and sera were collected: prior to the vaccination, 21 days after the first dose, and 14 days and 8 months after the second dose.
21 days after the first dose, 90.95% of individuals were seropositive; 14 days after the second dose, persistent immunity was observed in 99.18% HCWs, 8 months after complete vaccination-in 61.73%. Statistical analysis revealed that HCWs with PH had a greater chance of maintaining a humoral response beyond eight months after vaccination. Increased muscle mass, decreased fat mass, and younger age may positively affect long-term immunity. Smokers have a reduced chance of developing immunity compared to non-smokers.
Fully vaccinated HCWs with PH are more likely to be seropositive than fully inoculated volunteers with NPH.
本研究旨在调查 2 剂 BNT162b2 疫苗接种后医护人员（HCWs）的早期和纵向体液免疫反应，并评估代谢和人体测量参数与接种后体液免疫反应之间的关联。
本研究纳入了 243 名完全接种疫苗的 HCWs：25.50%既往感染过 SARS-CoV-2（有 COVID-19-PH 既往史），74.40%-未感染，首次接种前血清学阴性（无 COVID-19-NPH 既往史）。测量 IgG 抗体，并采集血清：接种前、第一剂后 21 天、第二剂后 14 天和 8 个月。
第一剂后 21 天，90.95%的人呈血清阳性；第二剂后 14 天，99.18%的 HCWs 持续存在免疫，完全接种 8 个月后-61.73%。统计分析显示，有 PH 的 HCWs 在接种后 8 个月以上保持体液反应的可能性更大。肌肉量增加、脂肪量减少和年龄较小可能对长期免疫产生积极影响。与不吸烟者相比，吸烟者产生免疫的机会减少。
与完全接种疫苗的 PH 志愿者相比，完全接种疫苗的 HCWs 更有可能呈血清阳性。
