Gao Kun, Qu Guangbo, Zhang Cuihong, Li Huaibiao, Sun Liang
Department of Geriatrics, Fuyang People's Hospital of Anhui Province, Fuyang 236006, China.
Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei 230032, China.
Vaccines (Basel). 2022 Oct 19;10(10):1750. doi: 10.3390/vaccines10101750.
This study investigated the effect of influenza vaccination on prevention of acute attacks in elderly patients with chronic airway disease and provides evidence for the prevention and control strategy of chronic airway disease in the elderly population. A total of 348 elderly patients in Linquan County, Anhui Province, China, who were also in stationary phases of chronic airway disease and were vaccinated with either the tetravalent or trivalent influenza vaccine were selected. The number of patients with acute attacks, the number of outpatients with acute attacks, the number of outpatients, the number of inpatients, the total cost of patients, the cost of outpatients, the cost of hospitalization, and the length of hospitalization were collected before vaccination and after a one-year follow-up. There was no significant difference in age and sex ratio among the two vaccination groups. The ratios of acute attacks, outpatient visits, and hospitalizations and number of outpatient visits, number of hospitalizations, total medical expenses, outpatient expenses, and hospitalization expenses were significantly higher before vaccination than those after vaccination in both the trivalent-vaccination group and tetravalent-vaccination group. Additionally, there was no significant difference in the length of stay between before and after vaccination in either the trivalent-vaccination group or tetravalent-vaccination group. The protection effect between the trivalent-vaccination group and tetravalent-vaccination group was not significant. Influenza vaccination can effectively prevent the acute attack of chronic airway disease and delay the progress of chronic airway disease.
本研究探讨流感疫苗接种对老年慢性气道疾病患者急性发作预防的影响，为老年人群慢性气道疾病的防控策略提供依据。选取中国安徽省临泉县348例处于慢性气道疾病稳定期且接种了四价或三价流感疫苗的老年患者。收集接种疫苗前及随访一年后的急性发作患者数、急性发作门诊患者数、门诊患者数、住院患者数、患者总费用、门诊费用、住院费用及住院天数。两个疫苗接种组的年龄和性别比无显著差异。三价疫苗接种组和四价疫苗接种组接种疫苗前的急性发作率、门诊就诊率、住院率以及门诊就诊次数、住院次数、总医疗费用、门诊费用和住院费用均显著高于接种疫苗后。此外，三价疫苗接种组和四价疫苗接种组接种疫苗前后的住院天数无显著差异。三价疫苗接种组和四价疫苗接种组之间的保护效果无显著差异。流感疫苗接种可有效预防慢性气道疾病的急性发作，延缓慢性气道疾病的进展。
