Bhattacharjee Rahul, Das Debanjan, Bhadhuri Radheka, Chakraborty Srija, Dey Tanima, Buragohain Rupam, Nath Asim, Muduli Kartik, Barman Pranjan, Gundamaraju Rohit
KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India.
St. Xavier's College (Autonomous), Kolkata, West Bengal, India.
J Oncol. 2022 Oct 17;2022:5231022. doi: 10.1155/2022/5231022. eCollection 2022.
COVID-19 resulted in a mortality rate of 3-6% caused by SARS-CoV-2 and its variant leading to unprecedented consequences of acute respiratory distress septic shock and multiorgan failure. In such a situation, evaluation, diagnosis, treatment, and care for cancer patients are difficult tasks faced by medical staff. Moreover, patients with gynaecological cancer appear to be more prone to severe infection and mortality from COVID-19 due to immunosuppression by chemotherapy and coexisting medical disorders. To deal with such a circumtances oncologists have been obliged to reconsider the entire diagnostic, treatment, and management approach. This review will provide and discuss the molecular link with gynaecological cancer under COVID-19 infection, providing a novel bilateral relationship between the two infections. Moreover, the authors have provided insights to discuss the pathobiology of COVID-19 in gynaecological cancer and their risks associated with such comorbidity. Furthermore, we have depicted the overall impact of host immunity along with guidelines for the treatment of patients with gynaecological cancer under COVID-19 infection. We have also discussed the feasible scope for the management of COVID-19 and gynaecological cancer.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）及其变体导致的2019冠状病毒病（COVID-19）死亡率为3%-6%，引发了急性呼吸窘迫、感染性休克和多器官功能衰竭等前所未有的后果。在这种情况下，对癌症患者的评估、诊断、治疗和护理是医务人员面临的艰巨任务。此外，由于化疗导致的免疫抑制和并存的内科疾病，妇科癌症患者似乎更容易因COVID-19而发生严重感染和死亡。为应对这种情况，肿瘤学家不得不重新考虑整个诊断、治疗和管理方法。本综述将阐述并讨论COVID-19感染下与妇科癌症的分子联系，揭示这两种感染之间新的双向关系。此外，作者还深入探讨了COVID-19在妇科癌症中的病理生物学及其与此类合并症相关的风险。此外，我们描述了宿主免疫的总体影响以及COVID-19感染下妇科癌症患者的治疗指南。我们还讨论了COVID-19和妇科癌症管理的可行范围。
