Shaohua Yang, Bin Zheng, Mei Liu, Jingfei Zhai, Pingping Qiao, Yanping He, Liping Zhu, Jiexin Yan, Guoshun Mao
Fuyang People's Hospital Pediatrics, Fuyang, China.
Wenzhou Medical University, Wenzhou, Zhejiang, China.
Front Genet. 2022 Sep 28;13:1019321. doi: 10.3389/fgene.2022.1019321. eCollection 2022.
This study aims to evaluate the incidence of low birth weight (LBW) and related maternal risk factors (during pregnancy or childbirth) and neonatal outcomes. A retrospective cross-sectional study design was used to select 7,421 pregnant women who gave birth in our hospital from January 2018 to June 2021. The data were analyzed using STATA 14.1, and the dependent variable (LBW) and risk were analyzed by the chi-square test of independence. The association between factors is used to determine the factors related to LBW through bivariate and multivariate logistic regression. The incidence of LBW in this study was 4.77%. Compared with single pregnant women, the probability of newborn LBW in married pregnant women is 40% lower (AOR = 0.60 95%CI: 0.40-0.90, = 0.013). Compared with gestational age less than 37 weeks, the LBW probability of gestational age 37-42 and 42 weeks or older is 85 and 81% lower respectively (AOR = 0.15 95% CI: 0.10-0.24, = 0.001; AOR = 0.19 95 %CI: 0.09-38, = 0.001), compared with normal pregnant women, the probability of neonatal LBW among pregnant women with hypertension is 94% higher [AOR = 1.94 (95% CI: 1.39-2.74, = 0.001). Compared with neonates with normal birth weight, neonates with LBW are at Apgar 1 min And Apgar 5 min score is lower than 7 (AOR = 0.52 95%CI: 0.37-0.73, = 0.001, AOR = 0.54 95%CI: 0.38-0.75, = 0.001) higher risk. In conclusion, women's marital status (single), gestational age (<37 weeks), and combined hypertension are independently associated with LBW, and the higher risk of Apgar 1 min and Apgar 5 min scores <7 is an independent result of LBW.
本研究旨在评估低出生体重（LBW）的发生率、相关的孕产妇风险因素（孕期或分娩期间）及新生儿结局。采用回顾性横断面研究设计，选取2018年1月至2021年6月在我院分娩的7421名孕妇。数据采用STATA 14.1进行分析，通过独立性卡方检验分析因变量（低出生体重）和风险。通过双变量和多变量逻辑回归分析因素之间的关联，以确定与低出生体重相关的因素。本研究中低出生体重的发生率为4.77%。与单胎孕妇相比，已婚孕妇新生儿低出生体重的概率低40%（调整后比值比[AOR]=0.60，95%置信区间[CI]：0.40 - 0.90，P = 0.013）。与孕周小于37周相比，孕周37 - 42周和42周及以上的低出生体重概率分别低85%和81%（AOR = 0.15，95%CI：0.10 - 0.24，P = 0.001；AOR = 0.19，95%CI：0.09 - 0.38，P = 0.001）。与正常孕妇相比，患有高血压的孕妇新生儿低出生体重的概率高94%[AOR = 1.94（95%CI：1.39 - 2.74，P = 0.001）]。与出生体重正常的新生儿相比，低出生体重新生儿1分钟和5分钟阿氏评分低于7分的风险更高（AOR = 0.52，95%CI：0.37 - 0.73，P = 0.001；AOR = 0.54，95%CI：0.38 - 0.75，P = 0.001）。总之，可以得出结论，女性的婚姻状况（单身）、孕周（<37周）和合并高血压与低出生体重独立相关，且1分钟和5分钟阿氏评分<7分的较高风险是低出生体重的独立结果。
