• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

首例抗PD-1治疗后疑似纵隔纤维化病例

A First Suspected Case of Fibrosing Mediastinitis After Anti-PD-1 Therapy.

作者信息

Park Carolyn J, Vasu Sujethra, Urbain Jean L, Triozzi Pierre L, Pokharel Yashashwi

机构信息

Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Section on Cardiovascular Medicine, Department of Internal Medicine and the Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

出版信息

JACC Case Rep. 2022 Oct 19;4(20):1363-1365. doi: 10.1016/j.jaccas.2022.09.002.

DOI:10.1016/j.jaccas.2022.09.002
PMID:36299648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9588595/
Abstract

We describe a first suspected case of fibrosing mediastinitis following anti-programmed death (PD)-1 therapy, pembrolizumab. Multimodality imaging, including cardiac magnetic resonance imaging, and a multidisciplinary team approach were integral to the diagnosis. If further substantiated, systematic surveillance after anti-PD-1 therapy for fibrosing mediastinitis may be warranted. ().

摘要

我们描述了首例怀疑为抗程序性死亡（PD）-1治疗药物帕博利珠单抗引发的纵隔纤维化病例。包括心脏磁共振成像在内的多模态成像以及多学科团队协作方法对诊断至关重要。如果得到进一步证实，抗PD-1治疗后对纵隔纤维化进行系统监测可能是必要的。（）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/681f/9588595/372fe3cf1116/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/681f/9588595/526de80c1d5b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/681f/9588595/372fe3cf1116/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/681f/9588595/526de80c1d5b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/681f/9588595/372fe3cf1116/gr1.jpg

相似文献

1
A First Suspected Case of Fibrosing Mediastinitis After Anti-PD-1 Therapy.首例抗PD-1治疗后疑似纵隔纤维化病例
JACC Case Rep. 2022 Oct 19;4(20):1363-1365. doi: 10.1016/j.jaccas.2022.09.002.
2
Hybrid Cardiac Magnetic Resonance/Fluorodeoxyglucose Positron Emission Tomography to Differentiate Active From Chronic Cardiac Sarcoidosis.心脏磁共振成像/氟脱氧葡萄糖正电子发射断层显像联合检查用于鉴别活动性与慢性心脏结节病
JACC Cardiovasc Imaging. 2022 Mar;15(3):445-456. doi: 10.1016/j.jcmg.2021.08.018. Epub 2021 Oct 13.
3
Late Gadolinium Enhancement Cardiac Magnetic Resonance Tissue Characterization for Cancer-Associated Cardiac Masses: Metabolic and Prognostic Manifestations in Relation to Whole-Body Positron Emission Tomography.晚期钆增强心脏磁共振组织特征分析在癌症相关心脏肿块中的应用：与全身正电子发射断层扫描相关的代谢和预后表现。
J Am Heart Assoc. 2019 May 21;8(10):e011709. doi: 10.1161/JAHA.118.011709.
4
Diagnostic accuracy and prognostic value of simultaneous hybrid 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in cardiac sarcoidosis.18F-氟脱氧葡萄糖正电子发射断层扫描/磁共振成像在心脏结节病中的诊断准确性和预后价值。
Eur Heart J Cardiovasc Imaging. 2018 Jul 1;19(7):757-767. doi: 10.1093/ehjci/jex340.
5
Discrepancy between significant fibrosis and active inflammation in patients with cardiac sarcoidosis: combined and image fusion analysis of cardiac magnetic resonance and F fluorodeoxyglucose positron emission tomography.心脏结节病患者显著纤维化与活动性炎症之间的差异：心脏磁共振成像与F-氟脱氧葡萄糖正电子发射断层扫描的联合及图像融合分析
Eur J Hybrid Imaging. 2019 Jun 14;3(1):9. doi: 10.1186/s41824-019-0056-4.
6
Prevalence of newly diagnosed sarcoidosis in patients with ventricular arrhythmias: a cardiac magnetic resonance and 18F-FDG cardiac PET study.室性心律失常患者中新诊断结节病的患病率：一项心脏磁共振成像和18F-FDG心肌PET研究
Int J Cardiovasc Imaging. 2021 Apr;37(4):1361-1369. doi: 10.1007/s10554-020-02090-2. Epub 2020 Nov 22.
7
A Potential Role for F-18 FDG PET/CT in Evaluation and Management of Fibrosing Mediastinitis.F-18 FDG PET/CT在纤维性纵隔炎评估与管理中的潜在作用
Clin Nucl Med. 2007 Sep;32(9):703-6. doi: 10.1097/RLU.0b013e318125035b.
8
Risk assessment of patients with clinical manifestations of cardiac sarcoidosis with positron emission tomography and magnetic resonance imaging.采用正电子发射断层扫描和磁共振成像对心脏结节病临床表现患者进行风险评估。
Int J Cardiol. 2017 Aug 15;241:457-462. doi: 10.1016/j.ijcard.2017.03.033. Epub 2017 Mar 10.
9
The usefulness of repeated CMR and FDG PET/CT in the diagnosis of patients with initial possible cardiac sarcoidosis.重复心脏磁共振成像（CMR）和氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）在初始可能患有心脏结节病患者诊断中的应用价值
EJNMMI Res. 2021 Dec 20;11(1):129. doi: 10.1186/s13550-021-00870-y.
10
Fibrosing mediastinitis mimicking bronchogenic carcinoma.纤维性纵隔炎酷似支气管肺癌。
J Thorac Dis. 2013 Feb;5(1):E5-7. doi: 10.3978/j.issn.2072-1439.2012.07.03.

本文引用的文献

1
Anti-PD-1 associated retroperitoneal fibrosis.抗程序性死亡蛋白1相关的腹膜后纤维化
Rheumatology (Oxford). 2021 Sep 1;60(9):e329-e330. doi: 10.1093/rheumatology/keab264.
2
Pulmonary fibrosis and cytokine release syndrome after hyperactivation with sintilimab.信迪利单抗治疗后出现肺纤维化和细胞因子释放综合征。
J Clin Pharm Ther. 2020 Dec;45(6):1474-1477. doi: 10.1111/jcpt.13217. Epub 2020 Jul 14.
3
Retroperitoneal fibrosis in on-going anti-PD-1 immunotherapy detected with [F]-FDG PET/CT.[F]-FDG PET/CT检测到的正在接受抗PD-1免疫治疗的腹膜后纤维化。
Eur J Nucl Med Mol Imaging. 2019 Jul;46(8):1758-1759. doi: 10.1007/s00259-019-04352-1. Epub 2019 May 15.